

<!--

    MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMMMMMMMMNKKNMMMMMMMMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMMMMMMMMOllOMMMMMMMMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMMMMMMMNo..oNMMMMMMMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMWXOxdoc'..'codxOXWMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMWXOo:'..............':oOXWMMMMMMMMMMMM
    MMMMMMMMMMW0o,......................,o0WMMMMMMMMMM
    MMMMMMMMWKl'.....;oxOo......oOxo;.....'lKWMMMMMMMM
    MMMMMMMNx,....'o0NMMNl......lNMMN0o'....,xNMMMMMMM
    MMMMMMNd.....lKWMMMMO,......,0MMMMWKl.....dNMMMMMM
    MMMMMWx....'xNMMMMMNo........dWMMMMMNd'....xWMMMMM
    MMMMM0;....dWMMMMMMK;........;KMMMMMMNd....;0MMMMM
    MMMMWx....:KMMMMMMWx..........xWMMMMMMK;....xWMMMM
    MMMMWo....lNMMMMMMX:..........cXMMMMMMNl....oWMMMM
    MMMMWo....lNMMMMMMk'..........'kMMMMMMNc....oWMMMM
    MMMMMk'...;0MMMMMNl............lNMMMMM0,....kMMMMM
    MMMMMX:....lXMMMM0,....,::,....,0MMMMXl....:XMMMMM
    MMMMMMO,....lXMMWo...ckXWWXkc...dWMMXl....,OMMMMMM
    MMMMMMWk,....;kNKc;d0WMMMMMMW0o;cKNk;....,kWMMMMMM
    MMMMMMMW0c.....;ldKWMMMMMMMMMMWKdl;.....c0WMMMMMMM
    MMMMMMMMMNk;......;ldkO0000Okdl;......;kNMMMMMMMMM
    MMMMMMMMMMMNkc'....................'ckNMMMMMMMMMMM
    MMMMMMMMMMMMMWXko:,............,cokXWMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMMWNK0kxxxdxxkOKNWMMMMMMMMMMMMMMMMM
    MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM

# Copyright © Bunkodo Co., Ltd. All rights reserved

# ########################## Copyright Information Begin ##########################
# Font - License:
# 	Roboto >>
# 		> Copyright [2011] [Google, inc]
# 		>
# 		> Licensed under the Apache License, Version 2.0 (the "License");
# 		> you may not use this file except in compliance with the License.
# 		> You may obtain a copy of the License at
# 		>
# 		>     http://www.apache.org/licenses/LICENSE-2.0
# 		>
# 		> Unless required by applicable law or agreed to in writing, software
# 		> distributed under the License is distributed on an "AS IS" BASIS,
# 		> WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# 		> See the License for the specific language governing permissions and
# 		> limitations under the License.
#
# 	Material Icons Font >>
# 		> Copyright [2004] [Google, inc]
# 		>
# 		> Licensed under the Apache License, Version 2.0 (the "License");
# 		> you may not use this file except in compliance with the License.
# 		> You may obtain a copy of the License at
# 		>
# 		>     http://www.apache.org/licenses/LICENSE-2.0
# 		>
# 		> Unless required by applicable law or agreed to in writing, software
# 		> distributed under the License is distributed on an "AS IS" BASIS,
# 		> WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# 		> See the License for the specific language governing permissions and
# 		> limitations under the License.
#
# 	font-awesome >>
# 		> Font Awesome Free 5.5.0 by @fontawesome - https://fontawesome.com
#		> License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
#
# 	Noto Sans >>
# 		> Copyright [2004] [Google, inc] http://scripts.sil.org/cms/scripts/page.php?site_id=nrsi&id=OFL
#
# ======================= Library =======================
# Video Player: plyr - https://github.com/sampotts/plyr.git
# 	The MIT License (MIT)
#
# 	Copyright (c) 2017 Sam Potts
#
#   Permission is hereby granted, free of charge, to any person obtaining a copy
#   of this software and associated documentation files (the "Software"), to deal
#   in the Software without restriction, including without limitation the rights
#   to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
#   copies of the Software, and to permit persons to whom the Software is
#   furnished to do so, subject to the following conditions:
#
#   The above copyright notice and this permission notice shall be included in
#   all copies or substantial portions of the Software.
#
#   THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
#   IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
#   FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
#   AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
#   LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
#   OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
#   THE SOFTWARE.
#
# - - - - - - - - - - - - - - - - - - - - - - - - - - - -
#
# Top Slider: swiper - https://github.com/nolimits4web/swiper.git
# 	The MIT License (MIT)
#
# 	Copyright (c) 2014 Vladimir Kharlampidi
#
#   Permission is hereby granted, free of charge, to any person obtaining a copy
#   of this software and associated documentation files (the "Software"), to deal
#   in the Software without restriction, including without limitation the rights
#   to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
#   copies of the Software, and to permit persons to whom the Software is
#   furnished to do so, subject to the following conditions:
#
#   The above copyright notice and this permission notice shall be included in
#   all copies or substantial portions of the Software.
#
#   THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
#   IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
#   FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
#   AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
#   LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
#   OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
#   THE SOFTWARE.
#
# - - - - - - - - - - - - - - - - - - - - - - - - - - - -
#
# Lazy Image loading: lazysizes - https://www.npmjs.com/package/lazysizes?activeTab=readme
#   The MIT License (MIT)
#
#   Copyright (c) 2015 Alexander Farkas
#
#   Permission is hereby granted, free of charge, to any person obtaining a copy
#   of this software and associated documentation files (the "Software"), to deal
#   in the Software without restriction, including without limitation the rights
#   to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
#   copies of the Software, and to permit persons to whom the Software is
#   furnished to do so, subject to the following conditions:
#
#   The above copyright notice and this permission notice shall be included in all
#   copies or substantial portions of the Software.
#
#   THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
#   IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
#   FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
#   AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
#   LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
#   OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
#   SOFTWARE.
#
# ########################## Copyright Information END ##########################
-->

<!DOCTYPE html>
<html lang="ja">
<head>
	

<!--Charset-->
<meta charset="UTF-8">

<!-- Google Tag Manager -->
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
})(window,document,'script','dataLayer','GTM-WQMB7SM');</script>
<!-- End Google Tag Manager -->


<!--Preload-->
<meta http-equiv="x-dns-prefetch-control" content="on">
<link rel="preconnect dns-prefetch" href="//fonts.googleapis.com">
<link rel="preconnect dns-prefetch" href="//storage.googleapis.com">
<link rel="preconnect dns-prefetch" href="//www.googletagmanager.com">

<!--Viewport-->
<meta name="viewport" content="width=1200">
<meta http-equiv="X-UA-Compatible" content="ie=edge">


<!--Favicon-->
<link rel="apple-touch-icon" sizes="180x180" href="/favicons/apple-touch-icon.png">
<link rel="icon" type="image/png" sizes="32x32" href="/favicons/favicon-32x32.png">
<link rel="icon" type="image/png" sizes="16x16" href="/favicons/favicon-16x16.png">
<link rel="manifest" href="/favicons/site.webmanifest">
<link rel="mask-icon" href="/favicons/safari-pinned-tab.svg" color="#ff6800">
<link rel="shortcut icon" href="/favicons/favicon.ico">
<meta name="msapplication-TileColor" content="#da532c">
<meta name="msapplication-config" content="/favicons/browserconfig.xml">
<meta name="theme-color" content="#ee7800">

<!--font-->
<style>
	.fa,.fab,.fal,.far,.fas{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;text-rendering:auto;display:inline-block;font-style:normal;font-variant:normal;line-height:1}.fa-lg{font-size:1.33333em;line-height:.75em;vertical-align:-.0667em}.fa-xs{font-size:.75em}.fa-sm{font-size:.875em}.fa-1x{font-size:1em}.fa-2x{font-size:2em}.fa-3x{font-size:3em}.fa-4x{font-size:4em}.fa-5x{font-size:5em}.fa-6x{font-size:6em}.fa-7x{font-size:7em}.fa-8x{font-size:8em}.fa-9x{font-size:9em}.fa-10x{font-size:10em}.fa-fw{text-align:center;width:1.25em}.fa-ul{list-style-type:none;margin-left:2.5em;padding-left:0}.fa-ul>li{position:relative}.fa-li{left:-2em;line-height:inherit;position:absolute;text-align:center;width:2em}.fa-border{border:.08em solid #eee;border-radius:.1em;padding:.2em .25em .15em}.fa-pull-left{float:left}.fa-pull-right{float:right}.fa.fa-pull-left,.fab.fa-pull-left,.fal.fa-pull-left,.far.fa-pull-left,.fas.fa-pull-left{margin-right:.3em}.fa.fa-pull-right,.fab.fa-pull-right,.fal.fa-pull-right,.far.fa-pull-right,.fas.fa-pull-right{margin-left:.3em}.fa-spin{-webkit-animation:fa-spin 2s linear infinite;animation:fa-spin 2s linear infinite}.fa-pulse{-webkit-animation:fa-spin 1s steps(8) infinite;animation:fa-spin 1s steps(8) infinite}@-webkit-keyframes fa-spin{0%{transform:rotate(0deg)}to{transform:rotate(1turn)}}@keyframes fa-spin{0%{transform:rotate(0deg)}to{transform:rotate(1turn)}}.fa-rotate-90{-ms-filter:"progid:DXImageTransform.Microsoft.BasicImage(rotation=1)";transform:rotate(90deg)}.fa-rotate-180{-ms-filter:"progid:DXImageTransform.Microsoft.BasicImage(rotation=2)";transform:rotate(180deg)}.fa-rotate-270{-ms-filter:"progid:DXImageTransform.Microsoft.BasicImage(rotation=3)";transform:rotate(270deg)}.fa-flip-horizontal{-ms-filter:"progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1)";transform:scaleX(-1)}.fa-flip-vertical{transform:scaleY(-1)}.fa-flip-horizontal.fa-flip-vertical,.fa-flip-vertical{-ms-filter:"progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1)"}.fa-flip-horizontal.fa-flip-vertical{transform:scale(-1)}:root .fa-flip-horizontal,:root .fa-flip-vertical,:root .fa-rotate-90,:root .fa-rotate-180,:root .fa-rotate-270{filter:none}.fa-stack{display:inline-block;height:2em;line-height:2em;position:relative;vertical-align:middle;width:2.5em}.fa-stack-1x,.fa-stack-2x{left:0;position:absolute;text-align:center;width:100%}.fa-stack-1x{line-height:inherit}.fa-stack-2x{font-size:2em}.fa-inverse{color:#fff}.fa-angle-right:before{content:""}.fa-chevron-left:before{content:""}.fa-chevron-right:before{content:""}.sr-only{clip:rect(0,0,0,0);border:0;height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}.sr-only-focusable:active,.sr-only-focusable:focus{clip:auto;height:auto;margin:0;overflow:visible;position:static;width:auto}@font-face{font-family:Font Awesome\ 5 Free;font-style:normal;font-weight:900;src:url("data:font/truetype;charset=utf-8;base64,AAEAAAALAIAAAwAwR1NVQrj6uPQAAAQ0AAAAKk9TLzJAC017AAACNAAAAFZjbWFw8d2zpAAAAowAAAB0Z2x5Zs+4RKgAAAC8AAAA3mhlYWQRoWlhAAAByAAAADZoaGVhBEECOQAAAhAAAAAkaG10eAJAAAAAAAIAAAAADmxvY2EAkwBJAAABvAAAAAptYXhwAS4BAgAAAZwAAAAgbmFtZRN/LYIAAAMAAAABFHBvc3QACAAAAAAEFAAAACAAAQAAAAAA6AFhABQAADcHBiIvASY0PwEnJjQ/ATYyHwEWFOCIBxQHFgcHYGAHBxYHFAeIB6+IBwcXBxQHYGAHFAcXBweIBxQAAQAA/+UBJQGbABQAAD8BNjIfAR4BDwEXFgYPAQYiLwEmNCPCBxQHFgcBB5ubBwEHFgcUB8II0cIHBxYHFAebmwcUBxYHB8IHFAABAAD/5QElAZsAFAAAJQcGIi8BLgE/AScmNj8BNjIfARYUAR3CBxQHFgcBB5ubBwEHFgcUB8IIr8IHBxYHFAebmwcUBxYHB8IHFAAAAAABAAAABAD2ACAAAAAAAAIAAAAKAAoAAAD/AAAAAAAAAAAAAAAkAEkAbwAAAAEAAAABAACONwgJXw889QALAgAAAAAA2AIUbwAAAADYAhRv//T/ugKKAcwAAAAIAAIAAAAAAAAAAAAAAQAAAAFAAAAAAAAAAAEAAAHA/8AAAAKA//T/9QKKAAEAAAAAAAAAAAAAAAAAAAADAAEB9wGQAAUAAAGWAWYAAABHAZYBZgAAAPUAGQCEAAACAAUDAAAAAAAAAAAAAAAAAAAAAAAAAAAAAFBmRWQAQPBT8QUBwP/AAC4BzABGAAAAAQAAAAAAAAAAAAQAAAADAAAAJAAAAAQAAABMAAMAAQAAACQAAwAKAAAATAAEACgAAAAGAAQAAQAC8FTxBf//AADwU/EF//8Prw78AAEAAAAAAAAADAAAAAAAKAAAAAAAAAACAADwUwAA8FQAAAACAADxBQAA8QUAAAABAAAABwBaAAMAAQQJAAAAGAAAAAMAAQQJAAEAJgAYAAMAAQQJAAIACgA+AAMAAQQJAAMAMgBIAAMAAQQJAAQAMgBIAAMAAQQJAAUAFgB6AAMAAQQJAAYAKgCQAEYAbwBuAHQAIABBAHcAZQBzAG8AbQBlAEYAbwBuAHQAIABBAHcAZQBzAG8AbQBlACAANQAgAEYAcgBlAGUAUwBvAGwAaQBkAEYAbwBuAHQAIABBAHcAZQBzAG8AbQBlACAANQAgAEYAcgBlAGUAIABTAG8AbABpAGQAVgBlAHIAcwBpAG8AbgAgADUALgA1AEYAbwBuAHQAQQB3AGUAcwBvAG0AZQA1AEYAcgBlAGUAUwBvAGwAaQBkAAMAAAAAAAAABQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAQAAAAoAJgAoAAJERkxUAA5sYXRuABgABAAAAAD//wAAAAAAAAAAAAAAAA==") format("truetype")}.fa,.far,.fas{font-family:Font Awesome\ 5 Free}.fa,.fas{font-weight:900}

</style>

<!--Material Icons-->
<link href="https://fonts.googleapis.com/icon?family=Material+Icons&display=swap" rel="stylesheet">

<!--Link-->


<!--Link Scripts-->


<!--Title-->
<title>心臓を守る！ミネラルコルチコイド受容体拮抗薬 | 株式会社文光堂</title>


<!--Meta-->
<meta name="keywords" content="">

<!--Search Engine-->
<meta name="google-site-verification" content="dk6eaH3uVB2a6LvkvoM5kHzHbsQv-rQAKJ4v22R7IAc" />
<meta name="msvalidate.01" content="81D49167100494DE90EF4805B37085B0" />


<meta name="description" content="ミネラルコルチコイド受容体拮抗薬（MRA）は従来アルドステロン拮抗薬と言われていたものである．近年，ミネラルコルチコイド受容体（MR）の新たな作用機序が続々と明らかになり，高血圧，CKD，メタボ，2型糖尿病，動脈硬化，そして心不全の病態進展に重要な役割を果たすことがわかってきた．本書では，MRの最新の病態生理からMRAの臨床エビデンス，そして次世代の非ステロイド型MRAの可能性までをエキスパートに">

<!--<script async src="https://www.googletagmanager.com/gtag/js?id="></script>-->
<!--<script>-->
<!--	window.dataLayer = window.dataLayer || [];-->
<!--	function gtag(){dataLayer.push(arguments);}-->
<!--	gtag('js', new Date());-->

<!--	gtag('config', '');-->
<!--</script>-->

<!--PolyFill-->
<script>
	
</script>

<!--Style-->
<style>
	html{background:#fff;color:#000;font-family:sans-serif;font-size:16px;font-weight:400;min-width:1000px;position:absolute;width:100%}body,html{margin:0;padding:0}a{color:#000;text-decoration:none}img{border:none}span#ordernumber{color:#ee7800;font-family:monospace;font-size:2rem;vertical-align:bottom}div#previewBadge{background:#fff2f2;border:2px solid #e80000;border-radius:3px;font-size:.8rem;padding:2px 4px;position:fixed;right:20px;top:20px;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;z-index:65535}
.anchor>a,header>ul.header_detail>li>a{background:transparent;border-radius:3px;height:100%;width:100%}.anchor>a:active,.anchor>a:hover,header>ul.header_detail>li>a:active,header>ul.header_detail>li>a:hover{color:#ee7800}.bunkodo_font_style_A{color:#000;font-size:1.2rem;font-weight:400}.bunkodo_font_style_B{color:#000;font-size:1rem;font-weight:400}.bracketsList,.bunkodo_font_style_C{color:#000;font-size:.9rem;font-weight:lighter}.bracketsList>a,.bunkodo_font_style_C>a{color:#0091ea;margin-left:5px}.bracketsList>a>i,.bunkodo_font_style_C>a>i{font-size:17px!important;vertical-align:text-top!important}.bracketsList>a:hover,.bunkodo_font_style_C>a:hover{color:#1ea9ff}.bracketsList>a:active,.bunkodo_font_style_C>a:active{color:#51bdff}.bunkodo_font_style_D{color:#000;font-size:.87rem;font-weight:lighter}.bunkodo_font_style_D>a{color:#0091ea;margin-left:5px}.bunkodo_font_style_D>a>i{font-size:17px!important;vertical-align:text-top!important}.bunkodo_font_style_D>a:hover{color:#1ea9ff}.bunkodo_font_style_D>a:active{color:#51bdff}.bunkodo_font_style_link>a{color:#0091ea;font-size:14.5px;margin-left:5px}.bunkodo_font_style_link>a>i{font-size:17px!important;vertical-align:text-top!important}.bunkodo_font_style_link>a:hover{color:#1ea9ff}.bunkodo_font_style_link>a:active{color:#51bdff}.bracketsList{margin:20px 0;padding:0 0 0 3em}.bracketsList>li{counter-increment:cnt;list-style:none outside}.bracketsList>li:before{content:"（" counter(cnt) "）";display:marker;margin:0 0 0 -2.4rem}header{background:#fff;border-top:7px solid #f8b856;height:198px;position:relative;width:100%}header>ul.header_detail{background-color:#fff;clear:both;font-size:.8rem;height:20px;line-height:20px;list-style:none;margin:0 auto;overflow:hidden;padding:5px 0;position:relative;text-align:right;width:1000px}header>ul.header_detail>li{float:right;margin:0 0 0 5px;padding:0 5px}header>ul.header_detail>li>a>i{color:#9b9b9b}header>div.header_main{height:66px;margin:5px auto;padding:0 calc(50% - 500px);position:relative;width:1000px}header>div.header_main:after{background:#ee7800;content:"";display:block;height:50px;left:0;position:absolute;top:71px;width:100%}header>div.header_main>a{float:left;height:66px;width:auto}header>div.header_main>a>img{height:47px;margin-top:16px}header>div.header_main>ul{float:right;height:70px;list-style-type:none;margin:0;padding:0;position:relative;top:0;width:500px}header>div.header_main>ul>li>a{border-radius:5px;display:block;float:right;font-size:.62rem;height:70px;position:relative;text-align:center;width:64px}header>div.header_main>ul>li>a>.number{color:#e4223e;font-family:monospace!important;font-size:9px;font-weight:700;height:15px;line-height:15px;position:absolute;right:0;text-align:center;top:15px;width:100%}header>div.header_main>ul>li>a:hover{background:rgba(0,0,0,.1)}header>div.header_main>ul>li>a:active{background:rgba(0,0,0,.2)}header>div.header_main>ul>li>a:before{content:"";display:block;height:40px;margin:5px auto;position:relative;width:40px}header>div.header_main>ul>li>a.login:before,header>div.header_main>ul>li>a:before{background:url(/images/sprite/topSprite.svg?v=4) no-repeat 0 0;background-size:40px 360px}header>div.header_main>ul>li>a.cart:before{background:url(/images/sprite/topSprite.svg?v=4) no-repeat 0 -40px;background-size:40px 360px}header>div.header_main>ul>li>a.twitter:before{background:url(/images/sprite/topSprite.svg?v=4) no-repeat 0 -80px;background-size:40px 360px}header>div.header_main>ul>li>a.facebook:before{background:url(/images/sprite/topSprite.svg?v=4) no-repeat 0 -200px;background-size:40px 360px}header>div.header_main>ul>li>a.home:before{background:url(/images/sprite/topSprite.svg?v=4) no-repeat 0 -120px;background-size:40px 360px}header>div.header_search{background:#f0f0f0;bottom:0;height:28px;line-height:28px;margin:0 auto;padding:7px calc(50% - 500px);position:absolute;text-align:center;width:1000px}header>div.header_search>form{clear:both;text-align:center}header>div.header_search>form,header>div.header_search>form>.search{display:inline-block;height:28px;margin:0 auto;overflow:hidden;position:relative}header>div.header_search>form>.search{border-radius:28px;padding:0;width:470px}header>div.header_search>form>.search>.searchKeyOverlay{background:#fff;border:none;float:left;font-size:.8rem;height:28px;line-height:28px;margin:0;overflow:hidden;padding:0;position:relative;text-align:left;width:140px}header>div.header_search>form>.search>.searchKeyOverlay>span#searchKeyName{padding:0 0 0 10px;position:relative;text-align:left;top:1px}header>div.header_search>form>.search>.searchKeyOverlay:after{background:#9b9b9b url(/images/sprite/search_ber.svg?v=3) no-repeat -212px 0;background-size:310px 28px;content:"";display:block;height:28px;position:absolute;right:0;top:0;width:15px}header>div.header_search>form>.search>.searchKeyOverlay:hover{background:#cdcdcd}header>div.header_search>form>.search>.searchKeyOverlay>select{cursor:pointer;height:28px;left:0;opacity:0;position:absolute;top:0;width:100%;z-index:2}header>div.header_search>form>.search>input{border:none;float:left;font-size:.9rem;height:28px;line-height:28px;margin:0;outline:#9b9b9b;padding:0 10px;position:relative;width:260px}header>div.header_search>form>.search>button{background:#fff url(/images/sprite/search_ber.svg?v=3) no-repeat 0 0;background-size:310px 28px;border:none;border-left:2px solid #9b9b9b;cursor:pointer;float:left;height:28px;margin:0;outline:#fff;padding:0;position:relative;width:50px}header>div.header_search>form>.search>button:hover{background-color:#cdcdcd}header>div.header_search>form>.search>button:active{background-color:#9b9b9b}header>div.header_search>form>.options{border-radius:28px;display:inline-block;font-size:.8rem;height:28px;margin:0 0 0 30px;overflow:hidden;padding:0;position:relative;text-align:left;width:360px}header>div.header_search>form>.options>span{float:left;margin-right:10px}header>div.header_search>form>.options>.sortKeyOverlay{background:#fff;float:left;font-size:.8rem;height:28px;margin-right:20px;padding-right:15px;position:relative;text-align:center;width:135px}header>div.header_search>form>.options>.sortKeyOverlay:after{background:#9b9b9b url(/images/sprite/search_ber.svg?v=3) no-repeat -212px 0;background-size:310px 28px;content:"";display:block;height:28px;position:absolute;right:0;top:0;width:15px}header>div.header_search>form>.options>.sortKeyOverlay:hover{background:#cdcdcd}header>div.header_search>form>.options>.sortKeyOverlay>select{cursor:pointer;height:28px;left:0;opacity:0;position:absolute;top:0;width:100%;z-index:1}header>div.header_search>form>.options>div.view{float:left;font-size:0;height:28px}header>div.header_search>form>.options>div.view>button{border:none;content:"";cursor:pointer;height:28px;outline:#cd5c5c;padding:0 3px;position:relative;width:40px}header>div.header_search>form>.options>div.view>button.tile{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -50px 0;background-size:310px 28px}header>div.header_search>form>.options>div.view>button.tile:hover{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -230px 0;background-size:310px 28px}header>div.header_search>form>.options>div.view>button.tile.current,header>div.header_search>form>.options>div.view>button.tile:active{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -130px 0;background-size:310px 28px}header>div.header_search>form>.options>div.view>button.list{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -90px 0;background-size:310px 28px}header>div.header_search>form>.options>div.view>button.list:hover{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -270px 0;background-size:310px 28px}header>div.header_search>form>.options>div.view>button.list.current,header>div.header_search>form>.options>div.view>button.list:active{background:transparent url(/images/sprite/search_ber.svg?v=3) no-repeat -170px 0;background-size:310px 28px}header>nav.opened{height:auto}header>nav{height:50px;margin:0 auto;overflow:hidden;position:relative;width:1002px}header>nav>button{-webkit-appearance:none;-moz-appearance:none;background:#cdcdcd;border:none;color:#fff;cursor:pointer;display:block;font-size:16px;height:20px;line-height:20px;margin:0;overflow:hidden;padding:0;position:absolute;right:10px;text-align:center;top:60px;width:20px;z-index:30}header>nav>button:hover{background:#9b9b9b}header>nav>button>i{font-size:20px!important}header>nav>ul.index{clear:both;height:50px;list-style:none;margin:0 auto;padding:0;position:relative;width:1000px}header>nav>ul.index>li{color:#fff;cursor:pointer;float:left;font-size:1.2rem;height:50px;line-height:50px;position:relative;text-align:center;width:166.66667px}header>nav>ul.index>li>a{color:#fff;display:block;height:50px;position:relative;width:100%}header>nav>ul.index>li:hover{background:#bb5e04}header>nav>ul.detail{border-left:1px solid #9b9b9b;border-right:1px solid #9b9b9b;height:auto;list-style:none;margin:0;padding:0;position:relative;width:1000px;z-index:20}header>nav>ul.detail>li:not(.tab_top):after{background:#9b9b9b;clear:both;content:"";display:block;height:1px;position:relative;width:100%}header>nav>ul.detail>li{background:#803c00;background:linear-gradient(90deg,#803c00 56%,#fff 0);display:none;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr="#803c00",endColorstr="#ffffff",GradientType=1);height:auto;position:relative;width:100%}header>nav>ul.detail>li>h4{color:#fff;float:left;font-size:1.1rem;font-weight:400;margin:0;min-height:40px;padding:20px 0 0;position:relative;text-align:center;width:166.66667px}header>nav>ul.detail>li>div{background:#fff;border-collapse:collapse;float:left;padding:20px 0;position:relative;table-layout:fixed;width:calc(100% - 166.66667px)}header>nav>ul.detail>li>div>table{border-collapse:collapse;margin-left:20px;position:relative;table-layout:fixed;width:calc(100% - 20px)}header>nav>ul.detail>li>div>table>tbody>tr,header>nav>ul.detail>li>div>table>tr{color:#fff}header>nav>ul.detail>li>div>table>tbody>tr>th,header>nav>ul.detail>li>div>table>tr>th{background:#fff;color:#ee7800;font-size:.8rem;font-weight:400;padding:5px 15px;text-align:left}header>nav>ul.detail>li>div>table>tbody>tr>td,header>nav>ul.detail>li>div>table>tr>td{background:#fff;font-size:.8rem;padding:5px;text-align:left}header>nav>ul.detail>li>div>table>tbody>tr>td>a,header>nav>ul.detail>li>div>table>tr>td>a{border-radius:5px;color:#803c00;padding:5px 10px}header>nav>ul.detail>li>div>table>tbody>tr>td>a:hover,header>nav>ul.detail>li>div>table>tr>td>a:hover{background:#ffe7b8;color:#ee7800;font-weight:700}nav.breadCrumb{font-size:.8rem;height:20px;margin:0 auto;padding:10px 0 25px;position:relative;width:1000px}nav.breadCrumb>ul{clear:both;height:20px;list-style:none;margin:0;padding:0;width:100%}nav.breadCrumb>ul>li{float:left;margin-left:7px}nav.breadCrumb>ul>li>a{color:#ee7800;cursor:pointer}nav.breadCrumb>ul>li>a:hover{color:#f8b856}nav.breadCrumb>ul>li>i{color:#9b9b9b;margin-left:3px}nav.breadCrumb>ul>li:first-child{margin-left:0}div.steps{height:50px;margin:0 0 30px;overflow:hidden;width:100%}div.steps>ol{align-items:center;background:#fff;box-sizing:border-box!important;-js-display:flex;display:flex;height:50px;justify-content:flex-start;margin:0;padding:0 25px 0 0;white-space:nowrap;width:100%}div.steps>ol>li.current>div{background:#f8b856;color:#fff}div.steps>ol>li.current>div:after{background:#f8b856;background:linear-gradient(135deg,transparent 46%,#f8b856 0)}div.steps>ol>li:not(:first-child)>div:before{background:#fff;background:linear-gradient(135deg,transparent 50%,#fff 0);content:"";display:block;height:49.49747px;left:-24.74874px;position:absolute;top:.25126px;transform:rotate(-45deg);transform-origin:center center;width:49.49747px;z-index:0}div.steps>ol>li{flex-grow:1;height:50px;list-style:none;margin:0;padding:0;position:relative}div.steps>ol>li>div{background:#cdcdcd;color:#9b9b9b;font-size:1.1rem;height:50px;line-height:50px;padding:0 0 0 20px;position:relative;text-align:center;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;white-space:nowrap;width:calc(100% - 20px)}div.steps>ol>li>div:after{background:#cdcdcd;background:linear-gradient(135deg,transparent 46%,#cdcdcd 0);content:"";display:block;height:35.35534px;position:absolute;right:-17.67767px;top:7.32233px;transform:rotate(-45deg);transform-origin:center center;width:35.35534px;z-index:1}footer{background:#f0f0f0;border-top:7px solid #f8b856;height:100px;width:100%}footer>ul{align-content:center;cursor:pointer;-js-display:flex;display:flex;justify-content:center;list-style:none;margin:20px auto;max-width:1000px;padding:0;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}footer>ul>li{border-right:1px solid #000;font-size:.8rem;padding:0;position:relative;width:auto}footer>ul>li>a{box-sizing:border-box;display:block;font-size:.8rem;height:100%;padding:0 16px;white-space:nowrap;width:100%}footer>ul>li:last-child{border-right:none}footer>ul>li:hover{background:rgba(0,0,0,.1)}footer>ul>li.footer_list_last{border-right:none}footer>p{font-size:.65rem;text-align:center;width:100%}.buttonVariation>.w200,div.buttonset>.w200,div.buttonset>a>.w200{min-width:200px}.buttonVariation>button,div.buttonset>a>button,div.buttonset>button{-webkit-appearance:none;-moz-appearance:none;appearance:none;border-radius:5px;color:#fff;cursor:pointer;font-size:1.1rem;height:45px;line-height:40px;margin:0 10px;min-width:100px;padding:0 30px}.buttonVariation>button.gray,div.buttonset>a>button.gray,div.buttonset>button.gray{background:linear-gradient(180deg,#cdcdcd 0,#bbb);border:1px solid silver;color:#fff}.buttonVariation>button.gray:hover,div.buttonset>a>button.gray:hover,div.buttonset>button.gray:hover{background:#9b9b9b}.buttonVariation>button.gray:active,div.buttonset>a>button.gray:active,div.buttonset>button.gray:active{background:#828282}.buttonVariation>button.default,div.buttonset>a>button.default,div.buttonset>button.default{background:#ee7800;background:linear-gradient(180deg,#ee7800 0,#ed6300);border:1px solid #ee5900}.buttonVariation>button.default:hover,div.buttonset>a>button.default:hover,div.buttonset>button.default:hover{background:linear-gradient(180deg,#d56b00 0,#d45800)}.buttonVariation>button.default:active,div.buttonset>a>button.default:active,div.buttonset>button.default:active{background:#a25100}div.buttonset{height:45px;margin:50px 0;position:relative;text-align:center;width:100%}
ul.listNavRoot{list-style:none;margin:0 20px 0 0;padding:0;position:relative;width:200px}ul.listNavRoot>li:first-child{border:1px solid #000;height:48px;margin:0 0 10px;padding-left:50px;width:148px}ul.listNavRoot>li:first-child.book{background:transparent url(/images/sprite/listSprite.svg?v=3) no-repeat 0 -50px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine{background:transparent url(/images/sprite/listSprite.svg?v=3) no-repeat 0 0;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine1{background:transparent url(/images/sprite/listSprite.svg?v=3) no-repeat 0 -100px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine2{background:transparent url(/images/sprite/listSprite.svg?v=3) no-repeat 0 -150px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine3{background:transparent url(/images/sprite/listSprite.svg?v=3) no-repeat 0 -200px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine_m0001{background:transparent url(/images/sprite/listSprite2.svg?v=3) no-repeat 0 -50px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine_m0002{background:transparent url(/images/sprite/listSprite2.svg?v=3) no-repeat 0 -100px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine_m0003{background:transparent url(/images/sprite/listSprite2.svg?v=3) no-repeat 0 -150px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine_m0004{background:transparent url(/images/sprite/listSprite2.svg?v=3) no-repeat 0 -200px;background-size:300px 250px}ul.listNavRoot>li:first-child.magazine_m0000>h2,ul.listNavRoot>li:first-child.magazine_m0002>h2{transform:scaleX(.8);transform-origin:left;white-space:nowrap!important}ul.listNavRoot>li:first-child>h2{font-size:1.3rem;font-weight:400;height:48px;line-height:48px;margin:0;padding:0;position:relative;width:100%}ul.listNavRoot>li:last-child{margin:0 0 10px!important}ul.listNavRoot>li:not(:first-child){cursor:pointer;font-size:1.1rem;height:40px;line-height:40px;margin:0;padding:0;position:relative;width:200px}ul.listNavRoot>li:not(:first-child).deepCyan{border-radius:5px;color:#000;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}ul.listNavRoot>li:not(:first-child).deepCyan:before{background:#009c96;border-radius:100%;content:"";display:block;float:left;height:9px;margin:15.5px 7px 15.5px 5px;padding:0;position:relative;width:9px}ul.listNavRoot>li:not(:first-child).deepCyan:hover{background:#bfe6e5}ul.listNavRoot>li:not(:first-child).deepCyan:active{background:#99d7d5}ul.listNavRoot>li:not(:first-child).lightOrange{border-radius:5px;color:#000;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}ul.listNavRoot>li:not(:first-child).lightOrange:before{background:#f5ad4c;border-radius:100%;content:"";display:block;float:left;height:9px;margin:15.5px 7px 15.5px 5px;padding:0;position:relative;width:9px}ul.listNavRoot>li:not(:first-child).lightOrange:hover{background:#fdebd2}ul.listNavRoot>li:not(:first-child).lightOrange:active{background:#fbdeb7}ul.listNavRoot>li:not(:first-child).lightGreen{border-radius:5px;color:#000;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}ul.listNavRoot>li:not(:first-child).lightGreen:before{background:#b3cd20;border-radius:100%;content:"";display:block;float:left;height:9px;margin:15.5px 7px 15.5px 5px;padding:0;position:relative;width:9px}ul.listNavRoot>li:not(:first-child).lightGreen:hover{background:#ecf3c7}ul.listNavRoot>li:not(:first-child).lightGreen:active{background:#e1eba6}ul.listNavRoot>li:not(:first-child).cyan{border-radius:5px;color:#000;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}ul.listNavRoot>li:not(:first-child).cyan:before{background:#5cbac0;border-radius:100%;content:"";display:block;float:left;height:9px;margin:15.5px 7px 15.5px 5px;padding:0;position:relative;width:9px}ul.listNavRoot>li:not(:first-child).cyan:hover{background:#d6eeef}ul.listNavRoot>li:not(:first-child).cyan:active{background:#bee3e6}ul.listNavRoot>li:not(:first-child).pink{border-radius:5px;color:#000;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}ul.listNavRoot>li:not(:first-child).pink:before{background:#ed5b7d;border-radius:100%;content:"";display:block;float:left;height:9px;margin:15.5px 7px 15.5px 5px;padding:0;position:relative;width:9px}ul.listNavRoot>li:not(:first-child).pink:hover{background:#fbd6df}ul.listNavRoot>li:not(:first-child).pink:active{background:#f8bdcb}ul.listNavRoot>li:not(:first-child)>a{display:block;height:100%;position:relative;width:100%}.anchor>a{background:transparent;border-radius:3px;height:100%;width:100%}.anchor>a:active,.anchor>a:hover{color:#ee7800}.bunkodo_font_style_A{color:#000;font-size:1.2rem;font-weight:400}.bunkodo_font_style_B{color:#000;font-size:1rem;font-weight:400}.bracketsList,.bunkodo_font_style_C{color:#000;font-size:.9rem;font-weight:lighter}.bracketsList>a,.bunkodo_font_style_C>a{color:#0091ea;margin-left:5px}.bracketsList>a>i,.bunkodo_font_style_C>a>i{font-size:17px!important;vertical-align:text-top!important}.bracketsList>a:hover,.bunkodo_font_style_C>a:hover{color:#1ea9ff}.bracketsList>a:active,.bunkodo_font_style_C>a:active{color:#51bdff}.bunkodo_font_style_D{color:#000;font-size:.87rem;font-weight:lighter}.bunkodo_font_style_D>a{color:#0091ea;margin-left:5px}.bunkodo_font_style_D>a>i{font-size:17px!important;vertical-align:text-top!important}.bunkodo_font_style_D>a:hover{color:#1ea9ff}.bunkodo_font_style_D>a:active{color:#51bdff}.bunkodo_font_style_link>a,main>section>article.description>section>a{color:#0091ea;font-size:14.5px;margin-left:5px}.bunkodo_font_style_link>a>i,main>section>article.description>section>a>i{font-size:17px!important;vertical-align:text-top!important}.bunkodo_font_style_link>a:hover,main>section>article.description>section>a:hover{color:#1ea9ff}.bunkodo_font_style_link>a:active,main>section>article.description>section>a:active{color:#51bdff}.bracketsList{margin:20px 0;padding:0 0 0 3em}.bracketsList>li{counter-increment:cnt;list-style:none outside}.bracketsList>li:before{content:"（" counter(cnt) "）";display:marker;margin:0 0 0 -2.4rem}@-webkit-keyframes plyr-progress{to{background-position:25px 0}}@keyframes plyr-progress{to{background-position:25px 0}}.plyr{direction:ltr;font-family:Avenir,Avenir Next,Helvetica Neue,Segoe UI,Helvetica,Arial,sans-serif;max-width:100%;min-width:200px;position:relative}.plyr,.plyr *,.plyr :after,.plyr :before{box-sizing:border-box}.plyr a,.plyr button,.plyr input,.plyr label{touch-action:manipulation}.plyr:focus{outline:0}.plyr audio,.plyr video{border-radius:inherit;height:auto;vertical-align:middle;width:100%}.plyr input[type=range]{-moz-appearance:none;appearance:none;-webkit-appearance:none;background:transparent;border:none;cursor:pointer;display:block;height:20px;margin:0;padding:0;vertical-align:middle;width:100%}.plyr input[type=range]::-webkit-slider-runnable-track{background:transparent;border:0;border-radius:4px;height:8px;-webkit-user-select:none;user-select:none}.plyr input[type=range]::-webkit-slider-thumb{-webkit-appearance:none;background:#fff;border:2px solid transparent;border-radius:100%;box-shadow:0 1px 1px rgba(0,0,0,.15),0 0 0 1px rgba(0,0,0,.15);box-sizing:border-box;height:16px;margin-top:-4px;position:relative;-webkit-transition:background .2s ease,border .2s ease,transform .2s ease;transition:background .2s ease,border .2s ease,transform .2s ease;width:16px}.plyr input[type=range]::-moz-range-track{background:transparent;border:0;border-radius:4px;height:8px;-moz-user-select:none;user-select:none}.plyr input[type=range]::-moz-range-thumb{background:#fff;border:2px solid transparent;border-radius:100%;box-shadow:0 1px 1px rgba(0,0,0,.15),0 0 0 1px rgba(0,0,0,.15);box-sizing:border-box;height:16px;position:relative;-moz-transition:background .2s ease,border .2s ease,transform .2s ease;transition:background .2s ease,border .2s ease,transform .2s ease;width:16px}.plyr input[type=range]::-ms-track{background:transparent;border:0;color:transparent;height:8px}.plyr input[type=range]::-ms-fill-lower,.plyr input[type=range]::-ms-fill-upper{background:transparent;border:0;border-radius:4px;height:8px;-ms-user-select:none;user-select:none}.plyr input[type=range]::-ms-fill-lower{background:#ee7800}.plyr input[type=range]::-ms-thumb{background:#fff;border:2px solid transparent;border-radius:100%;box-shadow:0 1px 1px rgba(0,0,0,.15),0 0 0 1px rgba(0,0,0,.15);box-sizing:border-box;height:16px;margin-top:0;position:relative;-ms-transition:background .2s ease,border .2s ease,transform .2s ease;transition:background .2s ease,border .2s ease,transform .2s ease;width:16px}.plyr input[type=range]::-ms-tooltip{display:none}.plyr input[type=range]:focus{outline:0}.plyr input[type=range]::-moz-focus-outer{border:0}.plyr input[type=range].tab-focus:focus{outline-offset:3px}.plyr input[type=range]:active::-webkit-slider-thumb{background:#ee7800;border-color:#fff;transform:scale(1.25)}.plyr input[type=range]:active::-moz-range-thumb{background:#ee7800;border-color:#fff;transform:scale(1.25)}.plyr input[type=range]:active::-ms-thumb{background:#ee7800;border-color:#fff;transform:scale(1.25)}.plyr--video input[type=range].tab-focus:focus{outline:1px dotted hsla(0,0%,100%,.5)}.plyr--audio input[type=range].tab-focus:focus{outline:1px dotted rgba(86,93,100,.5)}.plyr__sr-only{clip:rect(1px,1px,1px,1px);border:0!important;height:1px!important;overflow:hidden;padding:0!important;position:absolute!important;width:1px!important}.plyr__video-wrapper{background:#000;border-radius:inherit;position:relative}.plyr__video-embed{border-radius:inherit;height:0;overflow:hidden;padding-bottom:56.25%;z-index:0}.plyr__video-embed iframe{border:0;height:100%;left:0;position:absolute;top:0;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:100%}.plyr__video-embed>div{padding-bottom:200%;position:relative;transform:translateY(-35.95%)}.plyr .plyr__video-embed iframe{pointer-events:none}.plyr video::-webkit-media-text-track-container{display:none}.plyr__captions{bottom:0;color:#fff;display:none;font-size:16px;font-weight:400;left:0;padding:20px;position:absolute;text-align:center;transform:translateY(-60px);transition:transform .3s ease;width:100%}.plyr__captions span{background:rgba(0,0,0,.7);border-radius:2px;-webkit-box-decoration-break:clone;box-decoration-break:clone;line-height:150%;padding:3px 10px}.plyr__captions span:empty{display:none}@media (min-width:768px){.plyr__captions{font-size:24px}}.plyr--captions-active .plyr__captions{display:block}.plyr--hide-controls .plyr__captions{transform:translateY(-20px)}@media (min-width:1024px){.plyr--fullscreen-active .plyr__captions{font-size:32px}}.plyr ::-webkit-media-controls{display:none}.plyr__controls{align-items:center;-js-display:flex;display:flex;line-height:1;text-align:center}.plyr__controls .plyr__progress,.plyr__controls .plyr__time,.plyr__controls>button{margin-left:5px}.plyr__controls .plyr__progress:first-child,.plyr__controls .plyr__time:first-child,.plyr__controls>button:first-child{margin-left:0}.plyr__controls .plyr__volume{margin-left:5px}.plyr__controls [data-plyr=pause]{margin-left:0}.plyr__controls button{background:transparent;border:0;border-radius:3px;color:inherit;cursor:pointer;display:inline-block;flex-shrink:0;overflow:visible;padding:7px;position:relative;transition:background .3s ease,color .3s ease,opacity .3s ease;vertical-align:middle}.plyr__controls button svg{fill:currentColor;display:block;height:18px;width:18px}.plyr__controls button:focus{outline:0}.plyr__controls .icon--captions-on,.plyr__controls .icon--exit-fullscreen,.plyr__controls .icon--muted{display:none}@media (min-width:480px){.plyr__controls .plyr__progress,.plyr__controls .plyr__time,.plyr__controls>button{margin-left:10px}}.plyr--hide-controls .plyr__controls{opacity:0;pointer-events:none}.plyr--video .plyr__controls{background:linear-gradient(transparent,rgba(0,0,0,.5));border-bottom-left-radius:inherit;border-bottom-right-radius:inherit;bottom:0;color:#fff;left:0;padding:50px 10px 10px;position:absolute;right:0;transition:opacity .3s ease}.plyr--video .plyr__controls button.tab-focus:focus,.plyr--video .plyr__controls button:hover{background:#ee7800;color:#fff}.plyr--audio .plyr__controls{background:#fff;border:1px solid #dbe3e8;border-radius:inherit;color:#565d64;padding:10px}.plyr--audio .plyr__controls button.tab-focus:focus,.plyr--audio .plyr__controls button:hover,.plyr__play-large{background:#ee7800;color:#fff}.plyr__play-large{border:4px solid;border-radius:100%;box-shadow:0 1px 1px rgba(0,0,0,.15);display:none;left:50%;padding:10px;position:absolute;top:50%;transform:translate(-50%,-50%);transition:all .3s ease;z-index:1}.plyr__play-large svg{fill:currentColor;display:block;height:20px;left:2px;position:relative;width:20px}.plyr__play-large:focus{outline:1px dotted hsla(0,0%,100%,.5)}.plyr .plyr__play-large{display:inline-block}.plyr--audio .plyr__play-large{display:none}.plyr--playing .plyr__play-large{opacity:0;visibility:hidden}.plyr--playing .plyr__controls [data-plyr=play],.plyr__controls [data-plyr=pause]{display:none}.plyr--playing .plyr__controls [data-plyr=pause]{display:inline-block}.plyr--captions-active .plyr__controls .icon--captions-on,.plyr--fullscreen-active .icon--exit-fullscreen,.plyr--muted .plyr__controls .icon--muted{display:block}.plyr--captions-active .plyr__controls .icon--captions-on+svg,.plyr--fullscreen-active .icon--exit-fullscreen+svg,.plyr--muted .plyr__controls .icon--muted+svg,.plyr [data-plyr=captions],.plyr [data-plyr=fullscreen]{display:none}.plyr--captions-enabled [data-plyr=captions],.plyr--fullscreen-enabled [data-plyr=fullscreen]{display:inline-block}.plyr__tooltip{background:rgba(0,0,0,.7);border-radius:3px;bottom:100%;color:#fff;font-size:14px;line-height:1.3;margin-bottom:10px;opacity:0;padding:5px 7.5px;pointer-events:none;position:absolute;transform:translate(-50%,10px) scale(.8);transform-origin:50% 100%;transition:transform .2s ease .1s,opacity .2s ease .1s;z-index:2}.plyr__tooltip:before{border-left:4px solid transparent;border-right:4px solid transparent;border-top:4px solid rgba(0,0,0,.7);bottom:-4px;content:"";height:0;left:50%;position:absolute;transform:translateX(-50%);width:0;z-index:2}.plyr__tooltip--visible,.plyr button.tab-focus:focus .plyr__tooltip,.plyr button:hover .plyr__tooltip{opacity:1;transform:translate(-50%) scale(1)}.plyr button:hover .plyr__tooltip{z-index:3}.plyr__controls button:first-child .plyr__tooltip{left:0;transform:translateY(10px) scale(.8);transform-origin:0 100%}.plyr__controls button:first-child .plyr__tooltip:before{left:16px}.plyr__controls button:last-child .plyr__tooltip{right:0;transform:translateY(10px) scale(.8);transform-origin:100% 100%}.plyr__controls button:last-child .plyr__tooltip:before{left:auto;right:16px;transform:translateX(50%)}.plyr__controls button:first-child .plyr__tooltip--visible,.plyr__controls button:first-child.tab-focus:focus .plyr__tooltip,.plyr__controls button:first-child:hover .plyr__tooltip,.plyr__controls button:last-child .plyr__tooltip--visible,.plyr__controls button:last-child.tab-focus:focus .plyr__tooltip,.plyr__controls button:last-child:hover .plyr__tooltip{transform:translate(0) scale(1)}.plyr__progress{display:none;flex:1;position:relative}.plyr__progress input[type=range]{position:relative;z-index:2}.plyr__progress input[type=range]::-webkit-slider-runnable-track{background:transparent}.plyr__progress input[type=range]::-moz-range-track{background:transparent}.plyr__progress input[type=range]::-ms-fill-upper{background:transparent}.plyr__progress .plyr__tooltip{left:0}.plyr .plyr__progress{display:inline-block}.plyr__progress--buffer,.plyr__progress--played,.plyr__volume--display{-moz-appearance:none;appearance:none;-webkit-appearance:none;border:none;border-radius:100px;height:8px;left:0;margin:-4px 0 0;padding:0;position:absolute;top:50%;vertical-align:top;width:100%}.plyr__progress--buffer::-webkit-progress-bar,.plyr__progress--played::-webkit-progress-bar,.plyr__volume--display::-webkit-progress-bar{background:transparent}.plyr__progress--buffer::-webkit-progress-value,.plyr__progress--played::-webkit-progress-value,.plyr__volume--display::-webkit-progress-value{background:currentColor;border-radius:100px;min-width:8px}.plyr__progress--buffer::-moz-progress-bar,.plyr__progress--played::-moz-progress-bar,.plyr__volume--display::-moz-progress-bar{background:currentColor;border-radius:100px;min-width:8px}.plyr__progress--buffer::-ms-fill,.plyr__progress--played::-ms-fill,.plyr__volume--display::-ms-fill{border-radius:100px}.plyr__progress--played,.plyr__volume--display{background:transparent;color:#ee7800;transition:none;z-index:1}.plyr__progress--played::-webkit-progress-value,.plyr__volume--display::-webkit-progress-value{border-bottom-right-radius:0;border-top-right-radius:0;max-width:99%;min-width:8px;-webkit-transition:none;transition:none}.plyr__progress--played::-moz-progress-bar,.plyr__volume--display::-moz-progress-bar{border-bottom-right-radius:0;border-top-right-radius:0;max-width:99%;min-width:8px;-moz-transition:none;transition:none}.plyr__progress--played::-ms-fill,.plyr__volume--display::-ms-fill{display:none}.plyr__progress--buffer::-webkit-progress-value{-webkit-transition:width .2s ease;transition:width .2s ease}.plyr__progress--buffer::-moz-progress-bar{-moz-transition:width .2s ease;transition:width .2s ease}.plyr__progress--buffer::-ms-fill{-ms-transition:width .2s ease;transition:width .2s ease}.plyr--video .plyr__progress--buffer,.plyr--video .plyr__volume--display{background:hsla(0,0%,100%,.25)}.plyr--video .plyr__progress--buffer{color:hsla(0,0%,100%,.25)}.plyr--audio .plyr__progress--buffer,.plyr--audio .plyr__volume--display{background:rgba(198,214,219,.67)}.plyr--audio .plyr__progress--buffer{color:rgba(198,214,219,.67)}.plyr--loading .plyr__progress--buffer{-webkit-animation:plyr-progress 1s linear infinite;animation:plyr-progress 1s linear infinite;background-image:linear-gradient(-45deg,rgba(0,0,0,.15) 25%,transparent 0,transparent 50%,rgba(0,0,0,.15) 0,rgba(0,0,0,.15) 75%,transparent 0,transparent);background-repeat:repeat-x;background-size:25px 25px;color:transparent}.plyr--video.plyr--loading .plyr__progress--buffer{background-color:hsla(0,0%,100%,.25)}.plyr--audio.plyr--loading .plyr__progress--buffer{background-color:rgba(198,214,219,.67)}.plyr__time{display:inline-block;font-size:14px;vertical-align:middle}.plyr__time+.plyr__time{display:none}@media (min-width:768px){.plyr__time+.plyr__time{display:inline-block}}.plyr__time+.plyr__time:before{content:"\2044";margin-right:10px}.plyr__volume{display:none}.plyr .plyr__volume{flex:1;position:relative}.plyr .plyr__volume input[type=range]{position:relative;z-index:2}@media (min-width:480px){.plyr .plyr__volume{display:block;max-width:60px}}@media (min-width:768px){.plyr .plyr__volume{max-width:100px}}.plyr--is-ios .plyr__volume,.plyr--is-ios [data-plyr=mute]{display:none!important}.plyr--fullscreen-active{background:#000;border-radius:0!important;bottom:0;height:100%;left:0;position:fixed;right:0;top:0;width:100%;z-index:10000000}.plyr--fullscreen-active video{height:100%}.plyr--fullscreen-active .plyr__video-wrapper{height:100%;width:100%}.plyr--fullscreen-active .plyr__video-embed{overflow:visible}.plyr--fullscreen-active .plyr__controls{bottom:0;left:0;position:absolute;right:0}.plyr--fullscreen-active.plyr--vimeo .plyr__video-wrapper{height:0;top:50%;transform:translateY(-50%)}main{display:block;margin:0 auto;position:relative;width:1000px}main>nav{float:left;margin-bottom:100px;width:240px}main>section.magazine{border-top:1px solid #cdcdcd;padding-top:10px}main>section.magazine>.flag{letter-spacing:5px;top:10px}main>section.book>span.flag{float:right;font-size:1rem;letter-spacing:15px;line-height:28px;margin:0 0 5px -5px;padding:0 20px 0 15px;position:relative!important;right:0;top:0;z-index:2}main>section.navigation{height:30px;position:relative;width:760px}main>section.navigation>a{align-items:center;-js-display:flex;display:flex;height:30px;position:relative}main>section.navigation>a.previous{float:left}main>section.navigation>a.previous>img{transform:rotate(180deg)}main>section.navigation>a.next{float:right}main>section.navigation>a>img{display:inline-block;height:25px;position:relative;vertical-align:center;width:25px}main>section.magazine>h1.title{font-size:1.8rem}main>section.magazine>h2.series,main>section.magazine>h2.subFeature,main>section.magazine>h2.subTitle{color:#000;font-size:1.2rem;font-weight:400;margin:8px 0;width:100%}main>section{float:left;position:relative;width:760px}main>section>span.flag{background:#e00032;color:#fff;font-size:1rem;height:30px;letter-spacing:15px;line-height:28px;margin:0 0 5px -5px;padding:0 20px 0 15px;position:absolute;right:0;top:0;width:75px;z-index:2}main>section>span.flag.preOrder{background:#ff0!important;color:#000!important;letter-spacing:0!important;white-space:nowrap!important;width:110px!important}main>section>span.magazineCopy{font-size:1.1rem}main>section>h1.catchCopy{border-bottom:1px solid #cdcdcd;color:#ee7800;font-size:1.3rem;font-weight:400;margin:0 0 10px;padding:0 0 10px;width:100%}main>section>h2.series,main>section>h2.subFeature,main>section>h2.subTitle{color:#000;font-size:1.1rem;font-weight:400;margin:8px 0;width:100%}main>section>h1.copy{font-size:1.2rem!important;margin-bottom:-10px!important;margin-top:0!important}main>section>h1.copy,main>section>h1.title,main>section>h2.copy{color:#000;font-size:1.4rem;font-weight:700;margin:10px 0;width:100%}main>section>h1.title{font-size:1.7rem}main>section>h1.title>span{font-size:1.3rem;font-weight:400;margin-left:1.7rem}main>section>h1.titleWidth{padding:15px 0}main>section>article.detail{border-top:1px solid #cdcdcd;margin:10px 0 0;padding:30px 0 0;position:relative;width:100%}main>section>article.detail:after{clear:both;content:"";display:block;height:1px;position:relative;width:100%}main>section>article.detail>.coverOuter{float:left;position:relative;text-align:center;width:43%}main>section>article.detail>.coverOuter>img{border:1px solid #cdcdcd;max-height:430px;max-width:100%}main>section>article.detail>.coverOuter>div.links{margin:20px 0 0;position:relative;width:100%}main>section>article.detail>.coverOuter>div.links>div{display:block;font-size:.8rem;height:auto;padding:6px 0;position:relative;text-align:left;width:100%}main>section>article.detail>.coverOuter>div.links>div>a>button{background:#fff;border:1px solid #9b9b9b;cursor:pointer;font-size:1rem;height:40px;margin:0 0 5px;position:relative;text-align:center;width:100%}main>section>article.detail>.coverOuter>div.links>div>a>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat 0 0;background-size:200px 38px;content:"";display:inline-block;height:38px;position:relative;vertical-align:middle;width:40px}main>section>article.detail>.coverOuter>div.links>div>a>button:hover{background:rgba(0,0,0,.1)}main>section>article.detail>.coverOuter>div.links>div>a>button:active{background:rgba(0,0,0,.3)}main>section>article.detail>.coverOuter>div.links>div>a.sample>button{color:#599800}main>section>article.detail>.coverOuter>div.links>div>a.sample>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat 0 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>div>a.back-number>button{color:#ff7600}main>section>article.detail>.coverOuter>div.links>div>a.back-number>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -110px 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>div>a.video>button{color:#008cc3}main>section>article.detail>.coverOuter>div.links>div>a.video>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -40px 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>div>a.notice>button{color:#7f2d01}main>section>article.detail>.coverOuter>div.links>div>a.notice>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -80px 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>div.noticeBlock>div.noticeButton,main>section>article.detail>.coverOuter>div.links>div>div.noticeBlock>div.noticeButton{background:#fff;border:1px solid #9b9b9b;box-sizing:border-box;color:#7f2d01;font:400 1rem system-ui;height:40px;margin:0 0 5px;padding:1px 7px 2px;position:relative;text-align:center;width:100%}main>section>article.detail>.coverOuter>div.links>div.noticeBlock>div.noticeButton:before,main>section>article.detail>.coverOuter>div.links>div>div.noticeBlock>div.noticeButton:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -80px 0;background-size:200px 38px;content:"";display:inline-block;height:38px;position:relative;vertical-align:middle;width:40px}main>section>article.detail>.coverOuter>div.links>a{display:block;font-size:.8rem;height:auto;padding:6px 0;position:relative;text-align:left;width:100%}main>section>article.detail>.coverOuter>div.links>a>button{background:#fff;border:1px solid #9b9b9b;cursor:pointer;font-size:1rem;height:40px;margin:0 0 5px;position:relative;text-align:center;width:100%}main>section>article.detail>.coverOuter>div.links>a>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat 0 0;background-size:200px 38px;content:"";display:inline-block;height:38px;position:relative;vertical-align:middle;width:40px}main>section>article.detail>.coverOuter>div.links>a>button:hover{background:rgba(0,0,0,.1)}main>section>article.detail>.coverOuter>div.links>a>button:active{background:rgba(0,0,0,.3)}main>section>article.detail>.coverOuter>div.links>a.sample>button{color:#599800}main>section>article.detail>.coverOuter>div.links>a.sample>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat 0 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>a.video>button{color:#008cc3}main>section>article.detail>.coverOuter>div.links>a.video>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -40px 0;background-size:200px 38px}main>section>article.detail>.coverOuter>div.links>a.notice>button{color:#7f2d01}main>section>article.detail>.coverOuter>div.links>a.notice>button:before{background:url(/images/sprite/detailSprite.svg?v=3) no-repeat -80px 0;background-size:200px 38px}main>section>article.detail>.detailOuter{float:left;margin:0 0 0 20px;position:relative;width:calc(57% - 20px)}main>section>article.detail>.detailOuter>ul.author,main>section>article.detail>.detailOuter>ul.property{border-bottom:1px solid #cdcdcd;list-style-type:none;margin:0;padding:0 0 10px;width:100%}main>section>article.detail>.detailOuter>ul.author>li,main>section>article.detail>.detailOuter>ul.property>li{min-height:24px;position:relative}main>section>article.detail>.detailOuter>ul.author>li.transparent:before,main>section>article.detail>.detailOuter>ul.property>li.transparent:before{background:transparent!important;color:transparent!important;-webkit-user-select:none!important;-moz-user-select:none!important;-ms-user-select:none!important;user-select:none!important}main>section>article.detail>.detailOuter>ul.author>li .transparent,main>section>article.detail>.detailOuter>ul.property>li .transparent{color:transparent;-webkit-user-select:none!important;-moz-user-select:none!important;-ms-user-select:none!important;user-select:none!important}main>section>article.detail>.detailOuter>ul.author>li.disc:before,main>section>article.detail>.detailOuter>ul.property>li.disc:before{background:#cdcdcd;border-radius:100%;content:"";display:block;float:left;height:8px;margin:8px 8px 8px 0;padding:0;position:relative;width:8px}main>section>article.detail>.detailOuter>ul.author>li.pad1em,main>section>article.detail>.detailOuter>ul.property>li.pad1em{padding-left:1em;text-indent:-1em}main>section>article.detail>.detailOuter>ul.author>li.pad1em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad1em.disc:before{left:-1em}main>section>article.detail>.detailOuter>ul.author>li.pad2em,main>section>article.detail>.detailOuter>ul.property>li.pad2em{padding-left:2em;text-indent:-2em}main>section>article.detail>.detailOuter>ul.author>li.pad2em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad2em.disc:before{left:-2em}main>section>article.detail>.detailOuter>ul.author>li.pad3em,main>section>article.detail>.detailOuter>ul.property>li.pad3em{padding-left:3em;text-indent:-3em}main>section>article.detail>.detailOuter>ul.author>li.pad3em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad3em.disc:before{left:-3em}main>section>article.detail>.detailOuter>ul.author>li.pad4em,main>section>article.detail>.detailOuter>ul.property>li.pad4em{padding-left:4em;text-indent:-4em}main>section>article.detail>.detailOuter>ul.author>li.pad4em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad4em.disc:before{left:-4em}main>section>article.detail>.detailOuter>ul.author>li.pad5em,main>section>article.detail>.detailOuter>ul.property>li.pad5em{padding-left:5em;text-indent:-5em}main>section>article.detail>.detailOuter>ul.author>li.pad5em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad5em.disc:before{left:-5em}main>section>article.detail>.detailOuter>ul.author>li.pad6em,main>section>article.detail>.detailOuter>ul.property>li.pad6em{padding-left:6em;text-indent:-6em}main>section>article.detail>.detailOuter>ul.author>li.pad6em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad6em.disc:before{left:-6em}main>section>article.detail>.detailOuter>ul.author>li.pad7em,main>section>article.detail>.detailOuter>ul.property>li.pad7em{padding-left:7em;text-indent:-7em}main>section>article.detail>.detailOuter>ul.author>li.pad7em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad7em.disc:before{left:-7em}main>section>article.detail>.detailOuter>ul.author>li.pad8em,main>section>article.detail>.detailOuter>ul.property>li.pad8em{padding-left:8em;text-indent:-8em}main>section>article.detail>.detailOuter>ul.author>li.pad8em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad8em.disc:before{left:-8em}main>section>article.detail>.detailOuter>ul.author>li.pad9em,main>section>article.detail>.detailOuter>ul.property>li.pad9em{padding-left:9em;text-indent:-9em}main>section>article.detail>.detailOuter>ul.author>li.pad9em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad9em.disc:before{left:-9em}main>section>article.detail>.detailOuter>ul.author>li.pad10em,main>section>article.detail>.detailOuter>ul.property>li.pad10em{padding-left:10em;text-indent:-10em}main>section>article.detail>.detailOuter>ul.author>li.pad10em.disc:before,main>section>article.detail>.detailOuter>ul.property>li.pad10em.disc:before{left:-10em}main>section>article.detail>.detailOuter>ul.property{padding:10px 0}main>section>article.detail>.detailOuter>div.price{font-size:1rem;height:45px;margin:10px 0 0;padding:10px 0 0;position:relative;vertical-align:bottom;width:100%}main>section>article.detail>.detailOuter>div.price>span{font-size:1.8rem;font-weight:700}main>section>article.detail>.detailOuter>a>button,main>section>article.detail>.detailOuter>button,main>section>article.detail>.detailOuter>form>button{background:#ff7e02;background:linear-gradient(180deg,#ff7e02 0,#ff6601);border:1px solid #ff5f00;border-radius:5px;color:transparent;cursor:pointer;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr="#ff7e02",endColorstr="#ff6601",GradientType=0);font-size:1.2rem;height:50px;margin:10px 0 0;position:relative;text-align:center;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:100%}main>section>article.detail>.detailOuter>a>button>img,main>section>article.detail>.detailOuter>button>img,main>section>article.detail>.detailOuter>form>button>img{display:block;height:40px;margin:4px auto;position:relative}main>section>article.detail>.detailOuter>a>button:hover,main>section>article.detail>.detailOuter>button:hover,main>section>article.detail>.detailOuter>form>button:hover{background:#e56e00;background:linear-gradient(180deg,#e56e00 0,#e55902);filter:progid:DXImageTransform.Microsoft.gradient(startColorstr="#e56e00",endColorstr="#e55902",GradientType=0)}main>section>article.detail>.detailOuter>a>button:hover>img,main>section>article.detail>.detailOuter>button:hover>img,main>section>article.detail>.detailOuter>form>button:hover>img{opacity:.9}main>section>article.detail>.detailOuter>a>button:active,main>section>article.detail>.detailOuter>button:active,main>section>article.detail>.detailOuter>form>button:active{background:#994700;background:linear-gradient(180deg,#994700 0,#993901);filter:progid:DXImageTransform.Microsoft.gradient(startColorstr="#994700",endColorstr="#993901",GradientType=0)}main>section>article.detail>.detailOuter>a>button:active>img,main>section>article.detail>.detailOuter>button:active>img,main>section>article.detail>.detailOuter>form>button:active>img{opacity:.8}main>section>article.detail>.detailOuter>a>button.reserved,main>section>article.detail>.detailOuter>button.reserved,main>section>article.detail>.detailOuter>form>button.reserved{background:#1da192;background:linear-gradient(180deg,#4ab3a6 0,#1a9082);border:1px solid #1b9486}main>section>article.detail>.detailOuter>a>button.reserved:hover,main>section>article.detail>.detailOuter>button.reserved:hover,main>section>article.detail>.detailOuter>form>button.reserved:hover{background:#1a9082;background:linear-gradient(180deg,#1a9082 0,#178174)}main>section>article.detail>.detailOuter>a>button.reserved:active,main>section>article.detail>.detailOuter>button.reserved:active,main>section>article.detail>.detailOuter>form>button.reserved:active{background:#0d4d44;background:linear-gradient(180deg,#0d4d44 0,#09352e)}main>section>article.detail>.detailOuter>a>button.inActive,main>section>article.detail>.detailOuter>a>button.inActive:active,main>section>article.detail>.detailOuter>a>button.inActive:hover,main>section>article.detail>.detailOuter>button.inActive,main>section>article.detail>.detailOuter>button.inActive:active,main>section>article.detail>.detailOuter>button.inActive:hover,main>section>article.detail>.detailOuter>form>button.inActive,main>section>article.detail>.detailOuter>form>button.inActive:active,main>section>article.detail>.detailOuter>form>button.inActive:hover{background:#9b9b9b!important;background:linear-gradient(180deg,#9b9b9b 0,#8a8a8a)!important;border:1px solid #666!important;cursor:default;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr="#9b9b9b",endColorstr="#8a8a8a",GradientType=0)!important;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}main>section>article.detail>.detailOuter>a>button.inActive:active>img,main>section>article.detail>.detailOuter>a>button.inActive:hover>img,main>section>article.detail>.detailOuter>a>button.inActive>img,main>section>article.detail>.detailOuter>button.inActive:active>img,main>section>article.detail>.detailOuter>button.inActive:hover>img,main>section>article.detail>.detailOuter>button.inActive>img,main>section>article.detail>.detailOuter>form>button.inActive:active>img,main>section>article.detail>.detailOuter>form>button.inActive:hover>img,main>section>article.detail>.detailOuter>form>button.inActive>img{opacity:1}main>section>article.detail>.detailOuter div.detailAvail{border-bottom:1px solid #cdcdcd;margin:10px 0;padding:0 0 10px;position:relative;width:100%}main>section>article.detail>.detailOuter div.detailAvail:after{clear:both;content:"";display:block;height:1px;position:relative;width:100%}main>section>article.detail>.detailOuter div.detailAvail>span{display:block;float:right;height:30px;line-height:29px;position:relative}main>section>article.detail>.detailOuter div.detailAvail>div.inventoryNotice{clear:both;color:#9b9b9b;font-size:.9rem;font-weight:400;padding:10px 0 0;text-align:right}main>section>article.detail>.detailOuter div.detailAvail>div.detailAvailStatus{border-radius:7px;float:right;height:24px;margin-left:15px;position:relative;text-align:center;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:48px}main>section>article.detail>.detailOuter div.detailAvail>div.detailAvailStatusInStock{border:2px solid #31c1ff;color:#31c1ff}main>section>article.detail>.detailOuter div.detailAvail>div.detailAvailStatusInsignificant{border:2px solid #4caf50;color:#4caf50}main>section>article.detail>.detailOuter div.detailAvail>div.detailAvailStatusOutOfStock{border:2px solid #e00032;color:#e00032}main>section>article.detail>.detailOuter div.ebooks{border-bottom:1px solid #cdcdcd;margin:12px 0;padding:0 0 10px;position:relative;width:100%}main>section>article.detail>.detailOuter div.ebooks>h5{background:#f0f0f0;color:#ee7800;font-size:.9rem;font-weight:400;height:30px;line-height:30px;margin:0 0 10px;padding:0;position:relative;text-align:center;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:100%}main>section>article.detail>.detailOuter div.ebooks>div.sites{font-size:0;height:65px;position:relative;text-align:left;width:100%}main>section>article.detail>.detailOuter div.ebooks>div.sites>a{border:1px solid #cdcdcd;display:inline-block;height:53px;margin:5px;position:relative;width:calc(50% - 15px)}main>section>article.detail>.detailOuter div.ebooks>div.sites>a>img{display:block;margin:0 auto;max-height:45px;max-width:calc(100% - 10px);padding:5px}main>section>article.detail>.detailOuter div.ebooks>div.sites>a:hover:after{background:rgba(0,0,0,.1);content:"";height:100%;left:0;position:absolute;top:0;width:100%}main>section>article.detail>.detailOuter div.ebooks>div.sites>a:active:after{background:rgba(0,0,0,.3);content:"";height:100%;left:0;position:absolute;top:0;width:100%}main>section>article.detail>.detailOuter p.ebook_info{padding-left:.8rem;word-break:auto-phrase}main>section>article.detail>.detailOuter p.ebook_info:before{content:"※";display:block;margin-left:-.8rem;position:absolute}main>section>article.detail>.detailOuter p{font-size:.8rem;margin:5px 0;padding:0;width:calc(100% - .8rem)}main>section>article.description{margin:70px 0 0;position:relative;width:100%}main>section>article.description>a{background:#f0f0f0;border:none;border-radius:5px;display:block;font-size:1rem;height:28px;line-height:28px;position:absolute;right:0;text-align:center;top:0;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:90px;z-index:1}main>section>article.description>a:hover{background:#cdcdcd}main>section>article.description>a:active{background:#9b9b9b}main>section>article.description>a>i{color:#ee7800}main>section>article.description>.headers{border-bottom:1px solid #9b9b9b;height:40px;position:relative;width:100%}main>section>article.description>.headers>h3{border-left:1px solid #9b9b9b;border-right:1px solid #9b9b9b;border-top:1px solid #9b9b9b;border-top-left-radius:7px;border-top-right-radius:7px;cursor:pointer;float:left;font-size:1.1rem;font-weight:400;height:40px;line-height:40px;margin:0 10px 0 0;padding:0;position:relative;text-align:center;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:150px}main>section>article.description>.headers>h3.current,main>section>article.description>.headers>h3:hover{background:rgba(0,0,0,.1)}main>section>article.description>.headers>h3:active{background:rgba(0,0,0,.3)}main>section>article.description>.headers:after{clear:both;content:"";display:block;height:1px;position:relative;width:100%}main>section>article.description>section{display:none;font-size:1rem;margin:0;padding:10px 0 100px;width:100%}main>section>article.description>section .detail_video{margin:0 auto;padding:10px 0;width:560px}main>section>article.description>section>iframe{display:block;height:315px;margin:0 auto;padding:10px 0}main>section>article.description>section.current{display:block}main:after,main>section:after{clear:both;content:"";display:block;height:1px;position:relative;width:100%}

</style>

<!--Scripts-->

<!--Embed Script Begin [share.js] -->
<script>
	(()=>{"use strict";(()=>{function e(e,n){for(var t=0;t<n.length;t++){var r=n[t];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}var n=function(){function n(){!function(e,n){if(!(e instanceof n))throw new TypeError("Cannot call a class as a function")}(this,n)}var t,r;return t=n,null,(r=[{key:"alert",value:function(e){function n(n){return e.apply(this,arguments)}return n.toString=function(){return e.toString()},n}((function(e){alert(e)}))},{key:"id",value:function(e){return document.getElementById(String(e).trim())}},{key:"cls",value:function(e){var n=[];return[].forEach.call(document.getElementsByClassName(e),(function(e){n.push(e)})),n}},{key:"recursionElement",value:function(e){var n=[];return function e(t){var r=Array.prototype.slice.call(t.children);n.push(t),r.forEach(e)}(e),n}}])&&e(t,r),n}();n.flags={header:{opened:!1}},n.headerElementList=[]})()})();
</script>
<!--Embed Script End -->

<!--Embed Script Begin [header.js] -->
<script>
	(()=>{"use strict";var e={174:(e,t)=>{function n(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}Object.defineProperty(t,"__esModule",{value:!0}),t.lib=void 0;var r=function(){function e(){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,e)}var t,r;return t=e,null,(r=[{key:"alert",value:function(e){function t(t){return e.apply(this,arguments)}return t.toString=function(){return e.toString()},t}((function(e){alert(e)}))},{key:"id",value:function(e){return document.getElementById(String(e).trim())}},{key:"cls",value:function(e){var t=[];return[].forEach.call(document.getElementsByClassName(e),(function(e){t.push(e)})),t}},{key:"recursionElement",value:function(e){var t=[];return function e(n){var r=Array.prototype.slice.call(n.children);t.push(n),r.forEach(e)}(e),t}}])&&n(t,r),e}();t.lib=r,r.flags={header:{opened:!1}},r.headerElementList=[]}},t={};function n(r){var i=t[r];if(void 0!==i)return i.exports;var a=t[r]={exports:{}};return e[r](a,a.exports,n),a.exports}(()=>{function e(e,n){var r="undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@@iterator"];if(!r){if(Array.isArray(e)||(r=function(e,n){if(e){if("string"==typeof e)return t(e,n);var r=Object.prototype.toString.call(e).slice(8,-1);return"Object"===r&&e.constructor&&(r=e.constructor.name),"Map"===r||"Set"===r?Array.from(e):"Arguments"===r||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(r)?t(e,n):void 0}}(e))||n&&e&&"number"==typeof e.length){r&&(e=r);var i=0,a=function(){};return{s:a,n:function(){return i>=e.length?{done:!0}:{done:!1,value:e[i++]}},e:function(e){throw e},f:a}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var l,o=!0,c=!1;return{s:function(){r=r.call(e)},n:function(){var e=r.next();return o=e.done,e},e:function(e){c=!0,l=e},f:function(){try{o||null==r.return||r.return()}finally{if(c)throw l}}}}function t(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}var r=n(174);function i(e){if(r.lib.flags.header.opened&&e.target){var t=e.target,n=r.lib.id("header_navigation");if(!n)return;r.lib.headerElementList.includes(t)&&!t.classList.contains("activeHandler")||t.classList.contains("ignoreHandler")||(r.lib.flags.header.opened=!1,n.classList.remove("opened"),e.preventDefault(),e.stopImmediatePropagation(),window.removeEventListener("click",i,!1))}}window.addEventListener("DOMContentLoaded",(function(t){var n=r.lib.id("header_navigation");if(n){var a=n.querySelector(".index"),l=n.querySelector(".detail");if(a&&l){var o,c={},s=e([].slice.call(l.children));try{for(s.s();!(o=s.n()).done;){var u=o.value,d=u.getAttribute("class");d&&(c[d]=u)}}catch(e){s.e(e)}finally{s.f()}r.lib.headerElementList=r.lib.recursionElement(n);var f=r.lib.id("header_close");if(f){f.addEventListener("click",i,!1);var v,y=e([].slice.call(a.children));try{for(y.s();!(v=y.n()).done;){var b=v.value;b.classList.contains("ignoreHandler")||b.addEventListener("click",(function(e){for(var t=this.getAttribute("class"),a=0,l=Object.keys(c);a<l.length;a++){var o=l[a];c[o].style.display="none"}null!==t&&c.hasOwnProperty(t)&&(c[t].style.display="block"),r.lib.flags.header.opened=!0,n.classList.add("opened"),e.preventDefault(),e.stopImmediatePropagation(),window.addEventListener("click",i,!1)}),!1)}}catch(e){y.e(e)}finally{y.f()}var h=r.lib.id("searchKey"),p=r.lib.id("sortKey"),m=r.lib.id("searchKeyName"),g=r.lib.id("sortKeyName"),E=r.lib.id("searchForm"),L=r.lib.id("sortForm"),w=r.lib.id("styleType"),k=r.lib.id("totile"),x=r.lib.id("tolist"),S=r.lib.id("searchKeyHidden");E&&(h&&m&&h.addEventListener("change",(function(e){m.innerHTML=h.options[h.selectedIndex].text,S&&(S.value=h.options[h.selectedIndex].value)})),p&&g&&L&&p.addEventListener("change",(function(e){g.innerHTML=p.options[p.selectedIndex].text,L.submit()})),k&&x&&w&&L&&(k.addEventListener("click",(function(e){w.value="tile",L.submit()})),x.addEventListener("click",(function(e){w.value="list",L.submit()}))))}}}}))})()})();
</script>
<!--Embed Script End -->

<!--Embed Script Begin [detail.js] -->
<script>
	(()=>{"use strict";var r={174:(r,e)=>{function t(r,e){for(var t=0;t<e.length;t++){var n=e[t];n.enumerable=n.enumerable||!1,n.configurable=!0,"value"in n&&(n.writable=!0),Object.defineProperty(r,n.key,n)}}Object.defineProperty(e,"__esModule",{value:!0}),e.lib=void 0;var n=function(){function r(){!function(r,e){if(!(r instanceof e))throw new TypeError("Cannot call a class as a function")}(this,r)}var e,n;return e=r,null,(n=[{key:"alert",value:function(r){function e(e){return r.apply(this,arguments)}return e.toString=function(){return r.toString()},e}((function(r){alert(r)}))},{key:"id",value:function(r){return document.getElementById(String(r).trim())}},{key:"cls",value:function(r){var e=[];return[].forEach.call(document.getElementsByClassName(r),(function(r){e.push(r)})),e}},{key:"recursionElement",value:function(r){var e=[];return function r(t){var n=Array.prototype.slice.call(t.children);e.push(t),n.forEach(r)}(r),e}}])&&t(e,n),r}();e.lib=n,n.flags={header:{opened:!1}},n.headerElementList=[]}},e={};function t(n){var a=e[n];if(void 0!==a)return a.exports;var o=e[n]={exports:{}};return r[n](o,o.exports,t),o.exports}(()=>{function r(r,t){var n="undefined"!=typeof Symbol&&r[Symbol.iterator]||r["@@iterator"];if(!n){if(Array.isArray(r)||(n=function(r,t){if(r){if("string"==typeof r)return e(r,t);var n=Object.prototype.toString.call(r).slice(8,-1);return"Object"===n&&r.constructor&&(n=r.constructor.name),"Map"===n||"Set"===n?Array.from(r):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?e(r,t):void 0}}(r))||t&&r&&"number"==typeof r.length){n&&(r=n);var a=0,o=function(){};return{s:o,n:function(){return a>=r.length?{done:!0}:{done:!1,value:r[a++]}},e:function(r){throw r},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var i,l=!0,c=!1;return{s:function(){n=n.call(r)},n:function(){var r=n.next();return l=r.done,r},e:function(r){c=!0,i=r},f:function(){try{l||null==n.return||n.return()}finally{if(c)throw i}}}}function e(r,e){(null==e||e>r.length)&&(e=r.length);for(var t=0,n=new Array(e);t<e;t++)n[t]=r[t];return n}var n=t(174);window.addEventListener("DOMContentLoaded",(function(e){var t=n.lib.id("description");if(t){var a=t.querySelector(".headers");if(a){var o=t.querySelectorAll("section");if(o){var i,l=Array.prototype.slice.call(a.children),c=Array.prototype.slice.call(o),u=[],s=r(l);try{for(s.s();!(i=s.n()).done;)for(var f=i.value,v=String(f.className).replace(/current/gi,"").trim(),y=0;y<c.length;y++)c[y].classList.contains(v)&&u.push({tab:f,paragraph:c[y]})}catch(r){s.e(r)}finally{s.f()}for(var d=function(){var e=h[p];e.tab.addEventListener("click",(function(t){var n,a=r(u);try{for(a.s();!(n=a.n()).done;){var o=n.value;o.tab.classList.remove("current"),o.paragraph.classList.remove("current")}}catch(r){a.e(r)}finally{a.f()}e.tab.classList.add("current"),e.paragraph.classList.add("current")}))},p=0,h=u;p<h.length;p++)d();plyr&&plyr.setup()}}}}))})()})();
</script>
<!--Embed Script End -->


    <!-- Plyr -->
    <script src="https://www.bunkodo.co.jp/plyr/plyr.js"></script>

	<!-- Content Meta  -->
	<meta scheme="ISBN" name="identifier" content="978-4-8306-1946-5">
</head>
<body>
<!-- Google Tag Manager (noscript) -->
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WQMB7SM"
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
<!-- End Google Tag Manager (noscript) -->


<header>
	<ul class="header_detail">
		<li>
			<a href="/inquiry.html">
				<i class="fas fa-angle-right"></i>
				お問い合わせ
			</a>
		</li>
		<li>
			<a href="/forbookstore.html">
				<i class="fas fa-angle-right"></i>
				書店様へ
			</a>
		</li>
		<li>
			<a href="/copyright.html">
				<i class="fas fa-angle-right"></i>
				転載許諾申請
			</a>
		</li>
		<li>
			<a href="/order.html">
				<i class="fas fa-angle-right"></i>
				ご注文について
			</a>
		</li>

		
				<li>
					<a href="/registration.html">
						<i class="fas fa-angle-right"></i>
						会員登録
					</a>
				</li>
		
	</ul>
	<div class="header_main">
		<a href="/index.html">
			<img src="/images/logo.svg" alt="TOPページへ" draggable="false">
		</a>
		<ul>
			<li>
				<a class="twitter" title="Twitterへのリンク" target="_blank" href="https://twitter.com/bunkodo_eigyo">営業部</a>
			</li>
            <li>
				<a class="twitter" title="Twitterへのリンク" target="_blank" href="https://twitter.com/bunkodo_editors">編集企画部</a>
			</li>
            <li>
				<a class="facebook" title="Facebookへのリンク" target="_blank" href="https://www.facebook.com/bunkodo1892/">文光堂公式</a>
			</li>
			<li>
				<a class="cart" href="/cart.html">
					カート
					
					<div class="number"></div>
				</a>
			</li>

			
                <li>
                    
                            <a class="login" href="/login.html?after=57DFB1D711D8C3098F9A2AB6E2629284A5741AED3CD15AA87D89BFB185738774">ログイン</a>
                    
                </li>
			
		</ul>
	</div>
	<nav id="header_navigation">
		<button class="activeHandler" id="header_close">
			<i class="material-icons activeHandler">close</i>
		</button>

		<ul class="index">
			<li class="tab_top ignoreHandler">
				<a class="ignoreHandler" href="/index.html">
					ＴＯＰ
				</a>
			</li>
			<li class="tab_book">新刊・近刊</li>
			<li class="tab_category">書&nbsp;&nbsp;籍</li>
			<li class="tab_magazine">雑&nbsp;&nbsp;誌</li>
			<li class="tab_ebook">電子版</li>
			<li class="tab_video">WEB&nbsp;連動企画</li>
		</ul>
		<ul class="detail">
			<li class="tab_top"></li>
			<li class="tab_book">
				<h4>新刊・近刊</h4>
				<div>
					<table>
						<tr>
							<td>
								<a href="/list/newest_books.html">新刊一覧</a>
							</td>
							<td>
								<a href="/list/schedule_books.html">今後の発行予定</a>
							</td>
							<td></td>
							<td></td>
							<td></td>
						</tr>
					</table>
				</div>
			</li>
			<li class="tab_category">
				<h4>書籍分類</h4>
				<div>
					<table>
						<tr>
							<td>
								<a href="/list/C0000.html">医学一般・辞典</a>
							</td>
							<td>
								<a href="/list/C0007.html">内科学一般</a>
							</td>
							<td>
								<a href="/list/C000F.html">リウマチ・膠原病</a>
							</td>
							<td>
								<a href="/list/C0016.html">外科学一般</a>
							</td>
                            <td>
								<a href="/list/C001D.html">眼科</a>
							</td>
						</tr>
						<tr>
							<td></td>
							<td>
								<a href="/list/C0008.html">救急</a>
							</td>
							<td>
								<a href="/list/C0010.html">糖尿病・生活習慣病</a>
							</td>
							<td>
								<a href="/list/C0017.html">整形外科</a>
							</td>
                            <td>
								<a href="/list/C001E.html">産婦人科</a>
							</td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0001.html">解剖学・組織学</a>
							</td>
							<td>
								<a href="/list/C0009.html">神経</a>
							</td>
							<td>
								<a href="/list/C0011.html">栄養・輸液</a>
							</td>
							<td>
								<a href="/list/C0018.html">スポーツ医学</a>
							</td>
                            <td>
								<a href="/list/C001F.html">耳鼻咽喉科</a>
							</td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0002.html">生理学・生化学</a>
							</td>
							<td>
								<a href="/list/C000A.html">感染症</a>
							</td>
							<td>
								<a href="/list/C0012.html">腎臓</a>
							</td>
							<td>
								<a href="/list/C0019.html">リハビリテーション</a>
							</td>
                            <td></td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0003.html">薬学・薬理学</a>
							</td>
							<td>
								<a href="/list/C000B.html">呼吸器</a>
							</td>
							<td>
								<a href="/list/C0013.html">血液</a>
							</td>
                            <td>
								<a href="/list/C0022.html">東洋医学</a>
							</td>
                            <td>
								<a href="/list/C0020.html">看護・介護</a>
							</td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0004.html">病理学</a>
							</td>
							<td>
								<a href="/list/C000C.html">循環器</a>
							</td>
							<td>
								<a href="/list/C0014.html">小児科</a>
							</td>
                            <td>
								<a href="/list/C001A.html">形成・美容外科</a>
							</td>
                            <td></td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0005.html">検査</a>
							</td>
							<td>
								<a href="/list/C000D.html">消化器</a>
							</td>
							<td>
								<a href="/list/C0015.html">精神科</a>
							</td>
                            <td>
								<a href="/list/C001B.html">皮膚科</a>
							</td>
                            <td>
                                <a href="/list/series.html">シリーズ一覧</a>
                            </td>
						</tr>
						<tr>
							<td>
								<a href="/list/C0006.html">画像・放射線</a>
							</td>
							<td>
								<a href="/list/C000E.html">内分泌・代謝</a>
							</td>
							<td>
                                <a href="/list/C0021.html">老年医学</a>
                            </td>
                            <td>
								<a href="/list/C001C.html">麻酔科</a>
							</td>
							<td></td>
						</tr>
					</table>
				</div>
			</li>
			<li class="tab_magazine">
				<h4>雑&nbsp;&nbsp;誌</h4>
				<div>
					<table>
						<tr>
							<td colspan="2">
								<a href="/list/magazines.html">雑誌一覧</a>
							</td>
							<th colspan="2">Medical Practice</th>
							<th colspan="2">心エコー</th>
							<th colspan="2">臨床スポーツ医学</th>
							<th colspan="2">病理と臨床</th>
						</tr>
						<tr>
							<td colspan="2">
								<a href="/adinfo.html">広告掲載案内</a>
							</td>
							<td colspan="2">
								<a href="/subscription/medical_practice.html">
									雑誌案内・年間購読
								</a>
							</td>
							<td colspan="2">
								<a href="/subscription/clinical_echocardiography.html">
									雑誌案内・年間購読
								</a>
							</td>
							<td colspan="2">
								<a href="/subscription/clinical_sports_medicine.html">
									雑誌案内・年間購読
								</a>
							</td>
							<td colspan="2">
								<a href="/subscription/pathology_and_clinical_medicine.html">
									雑誌案内・年間購読
								</a>
							</td>
						</tr>
						<tr>
							<td colspan="2"></td>


                                        <td colspan="2">
                                            <a href="/latest/M0000.html">
                                                最新号
                                            </a>
                                        </td>
                            
                                        <td colspan="2">
                                            <a href="/latest/M0001.html">
                                                最新号
                                            </a>
                                        </td>
                            
                                        <td colspan="2">
                                            <a href="/latest/M0002.html">
                                                最新号
                                            </a>
                                        </td>
                            
                                        <td colspan="2">
                                            <a href="/latest/M0003.html">
                                                最新号
                                            </a>
                                        </td>
                            
						</tr>
						<tr>
							<td colspan="2"></td>
							<td colspan="2">
								<a href="/list/M0000.html?from=backNumber">
									バックナンバー
								</a>
							</td>
							<td colspan="2">
								<a href="/list/M0001.html?from=backNumber">
									バックナンバー
								</a>
							</td>
							<td colspan="2">
								<a href="/list/M0002.html?from=backNumber">
									バックナンバー
								</a>
							</td>
							<td colspan="2">
								<a href="/list/M0003.html?from=backNumber">
									バックナンバー
								</a>
							</td>
						</tr>
						<tr>
							<td colspan="2"></td>
							<td colspan="2">
                                <a href="https://docs.google.com/forms/d/e/1FAIpQLSdZnxjX6jyPrc1TpuHCDlTjtdSztyTRfdO3esN9jXir3ZhcUg/viewform">
									読者アンケート
								</a>
                            </td>
							<td colspan="2">
								<a href="/instruction/clinical_echocardiography.html">
									雑誌投稿規定
								</a>
							</td>
							<td colspan="2">
                                <a href="https://docs.google.com/forms/d/e/1FAIpQLSctGWQ3nngtVDM2VoFnnLd9zbOm8uaqiCfGfo2H5XI3IWS4bg/viewform">
									読者アンケート
								</a>
                            </td>
							<td colspan="2">
								<a href="https://storage.googleapis.com/static_bunkodo/byori_guide-for-authors202401.pdf">
									雑誌投稿規定
								</a>
							</td>
						</tr>
                        <tr>
							<td colspan="2"></td>
							<td colspan="2"></td>
							<td colspan="2">
								<a href="https://docs.google.com/forms/d/e/1FAIpQLScwSTS8s5VPD-43PkRcSuyASfhIgZXKmsAMVZw0jm_jFWIG7A/viewform">
									読者アンケート
								</a>
							</td>
							<td colspan="2"></td>
							<td colspan="2">
								<a href="https://forms.gle/H5ueeqYyrB2pvBiT7">
									読者アンケート
								</a>
							</td>
						</tr>
					</table>
				</div>
			</li>
			<li class="tab_ebook">
				<h4>電子版</h4>
				<div>
					<table>
						<tr>
							<td>
								<a href="/list/ebooks.html">電子書籍</a>
							</td>
							<td>
								<a href="/list/emagazines.html">電子雑誌</a>
							</td>
							<td></td>
							<td></td>
							<td></td>
						</tr>
					</table>
				</div>
			</li>
			<li class="tab_video">
				<h4>WEB&nbsp;連動企画</h4>
				<div>
					<table>
						<tr>
							<td>
								<a class="movie_link" href="/videos/echocardiography.html">雑誌「心エコー」WEB動画</a>
							</td>
						</tr>
                        <tr>
                            <td>
                                <a class="movie_link" href="/videos/orthopedic_surgery_kp.html">書籍「整形外科手術Knack & Pitfalls」WEB動画</a>
                            </td>
                        </tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/fascia_release_basics_and_clinical_2.html">書籍「解剖・動作・エコーで導くFasciaリリースの基本と臨床　第2版」WEB動画</a>
							</td>
						</tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/fascia_release2.html">書籍「肩痛・拘縮肩に対するFasciaリリース」WEB動画</a>
							</td>
						</tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/exerciser_ultrasound_anatomy.html">書籍「運動療法のための運動器超音波機能解剖」WEB動画</a>
							</td>
						</tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/clinical_behavior_analysis.html">書籍「データに基づく臨床動作分析」WEB動画</a>
							</td>
						</tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/ocular_surgery.html">書籍「眼手術学」WEB動画</a>
							</td>
						</tr>
						<tr>
							<td>
								<a class="movie_link" href="/videos/neurosis_engineering_2.html">書籍「神経症候学 II　改訂第二版」 WEB動画</a>
							</td>
						</tr>
					</table>
				</div>
			</li>
		</ul>
	</nav>
	<div class="header_search">
		<form action="/list/search.html" method="get" id="searchForm" accept-charset="UTF-8">
			<input type="hidden" name="style" value="tile">
			<div class="search">
				<div class="searchKeyOverlay" title="検索対象を変える">
					<select name="searchKey" id="searchKey" title="searchKey">
						
								<option selected value="op00">書名</option>
							
								<option  value="op08">書名(電子版)</option>
							
								<option  value="op01">雑誌特集名</option>
							
								<option  value="op09">雑誌特集名(電子版)</option>
							
								<option  value="op02">書籍著者名</option>
							
								<option  value="op03">雑誌著者名</option>
							
								<option  value="op04">ISBN</option>
							
								<option  value="op05">雑誌コード</option>
							
								<option  value="op06">書籍発行年</option>
							
								<option  value="op07">雑誌発行年</option>
							
								<option  value="op10">書籍ID</option>
							
								<option  value="op11">雑誌ID</option>
							
					</select>
					<span id="searchKeyName">
						書名
					</span>
				</div>

				<input type="text" name="query" title="searchQuery" placeholder="キーワードを入力" spellcheck="false" value="">

				<button></button>
			</div>
		</form>

		
	</div>
</header>


<nav class="breadCrumb">
	<ul>
					<li>
						<a href="/index.html">
							TOP
						</a>
						<i class="fas fa-angle-right"></i>
					</li>
				
					<li>
						<a href="/list/C000C.html">
							書籍分類 - 循環器
						</a>
						<i class="fas fa-angle-right"></i>
					</li>
				
					<li>心臓を守る！ミネラルコルチコイド受容体拮抗薬</li>
				</ul>
</nav>


<main>
	<nav>
		

		<ul class="listNavRoot">
			<li class="book">
				<h2>書籍</h2>
			</li>
			
				<li class="deepCyan">
					<a target="_top" href="/list/newest_books.html" title="新刊一覧へのリンク">
						新刊一覧
					</a>
				</li>
			
				<li class="deepCyan">
					<a target="_top" href="/list/schedule_books.html" title="今後の発行予定へのリンク">
						今後の発行予定
					</a>
				</li>
			
				<li class="deepCyan">
					<a target="_top" href="/list/series.html" title="シリーズ一覧へのリンク">
						シリーズ一覧
					</a>
				</li>
			
		</ul>

		<ul class="listNavRoot">
			<li class="magazine">
				<h2>書籍分類</h2>
			</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0000.html" title="医学一般・辞典へのリンク">
						医学一般・辞典
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0001.html" title="解剖学・組織学へのリンク">
						解剖学・組織学
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0002.html" title="生理学・生化学へのリンク">
						生理学・生化学
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0003.html" title="薬学・薬理学へのリンク">
						薬学・薬理学
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0004.html" title="病理学へのリンク">
						病理学
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0005.html" title="検査へのリンク">
						検査
					</a>
				</li>
			
				<li class="lightOrange">
					<a target="_top" href="/list/C0006.html" title="画像・放射線へのリンク">
						画像・放射線
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0007.html" title="内科学一般へのリンク">
						内科学一般
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0008.html" title="救急へのリンク">
						救急
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0009.html" title="神経へのリンク">
						神経
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000A.html" title="感染症へのリンク">
						感染症
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000B.html" title="呼吸器へのリンク">
						呼吸器
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000C.html" title="循環器へのリンク">
						循環器
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000D.html" title="消化器へのリンク">
						消化器
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000E.html" title="内分泌・代謝へのリンク">
						内分泌・代謝
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C000F.html" title="リウマチ・膠原病へのリンク">
						リウマチ・膠原病
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0010.html" title="糖尿病・生活習慣病へのリンク">
						糖尿病・生活習慣病
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0011.html" title="栄養・輸液へのリンク">
						栄養・輸液
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0012.html" title="腎臓へのリンク">
						腎臓
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0013.html" title="血液へのリンク">
						血液
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0014.html" title="小児科へのリンク">
						小児科
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0015.html" title="精神科へのリンク">
						精神科
					</a>
				</li>
			
				<li class="lightGreen">
					<a target="_top" href="/list/C0021.html" title="老年医学へのリンク">
						老年医学
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C0016.html" title="外科学一般へのリンク">
						外科学一般
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C0017.html" title="整形外科へのリンク">
						整形外科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C0018.html" title="スポーツ医学へのリンク">
						スポーツ医学
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C0019.html" title="リハビリテーションへのリンク">
						リハビリテーション
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C0022.html" title="東洋医学へのリンク">
						東洋医学
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001A.html" title="形成・美容外科へのリンク">
						形成・美容外科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001B.html" title="皮膚科へのリンク">
						皮膚科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001C.html" title="麻酔科へのリンク">
						麻酔科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001D.html" title="眼科へのリンク">
						眼科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001E.html" title="産婦人科へのリンク">
						産婦人科
					</a>
				</li>
			
				<li class="cyan">
					<a target="_top" href="/list/C001F.html" title="耳鼻咽喉科へのリンク">
						耳鼻咽喉科
					</a>
				</li>
			
				<li class="pink">
					<a target="_top" href="/list/C0020.html" title="看護・介護へのリンク">
						看護・介護
					</a>
				</li>
			
		</ul>


	</nav>

	
	<section class="book">

		<h1 class="catchCopy">最新の作用機序から臨床エビデンスまで，MRAの知識をこの1冊でアップデート！</h1>
		

		<h1 class="title">心臓を守る！ミネラルコルチコイド受容体拮抗薬<span class="version"></span></h1>
		<h2 class="subTitle">MRAの実力をQ&Aで解き明かす</h2>

		<article class="detail">

			<div class="coverOuter">
				<img src="https://storage.googleapis.com/static_bunkodo/detail_ON6Z3J8AKG07A7RTYC5R.jpg" alt="カバー写真">

				<div class="links">
					
					
				</div>
			</div>

			<div class="detailOuter">

				<ul class="author">
				<li class="pad4em disc">
					編集：伊藤　浩（岡山大学大学院医歯薬学総合研究科循環器内科学教授）
				</li>
			</ul>

				<ul class="property"><li class="disc">B5判・148頁・2色刷</li><li class="disc">ISBN&nbsp;978-4-8306-1946-5</li><li class="disc">2019年3月5日発行</li></ul>

				
			<div class="price">
				定価
				<span>
					5,500
				</span>
				円 (本体 5,000円 ＋ 税10%)
			</div>

				
					<form action="/cart.html" method="post">
						<input type="hidden" name="action" value="addCart">
						<input type="hidden" name="target" value="book">
						<input type="hidden" name="pid" value="LXLXHRM97B">
						<button type="submit">
							<img src="/images/sprite/add_cart.svg" alt="カートに入れる" draggable="false">
						</button>
					</form>

				<div class="detailAvail">
					<div class="detailAvailStatus detailAvailStatusInStock">あり</div>
					<span>在庫</span>
					
				</div>

				
				<div class="ebooks">
					<h5>電子版販売サイト</h5>
					<div class="sites">
						<a target="_blank" href="https://kw.maruzen.co.jp/ims/itemDetail.html?itmCd=1030867047">
							<img src="https://storage.googleapis.com/static_bunkodo/ebook_maruzen.jpg" alt="電子書籍の販売サイト" draggable="">
						</a>
						<a target="_blank" href="https://ebookstore.m2plus.com/mproducts/9784830619465.html">
							<img src="https://storage.googleapis.com/static_bunkodo/ebook_m3com.jpg" alt="電子書籍の販売サイト" draggable="">
						</a></div>
					<div class="sites">
						<a target="_blank" href="https://store.isho.jp/search/detail/productId/2205730380">
							<img src="https://storage.googleapis.com/static_bunkodo/ebook_ishojp.jpg" alt="電子書籍の販売サイト" draggable="">
						</a>
						<a target="_blank" href="https://www.molcom.jp/products/detail/130222/">
							<img src="https://storage.googleapis.com/static_bunkodo/ebook_medicalonline.jpg" alt="電子書籍の販売サイト" draggable="">
						</a></div>
				</div>
				<p class='ebook_info'>
					上記の電子版販売サイトのボタンをクリックすると，外部のサイトに移動します．電子版の購入方法は各販売サイトにてご確認ください．
				</p>

			</div>

		</article>

		
			<article id="description" class="description">
				
		<div class="headers"><h3 class="current content">内容</h3><h3 class="preface">序文</h3><h3 class="indexes">主要目次</h3></div><section class="current content">ミネラルコルチコイド受容体拮抗薬（MRA）は従来アルドステロン拮抗薬と言われていたものである．近年，ミネラルコルチコイド受容体（MR）の新たな作用機序が続々と明らかになり，高血圧，CKD，メタボ，2型糖尿病，動脈硬化，そして心不全の病態進展に重要な役割を果たすことがわかってきた．本書では，MRの最新の病態生理からMRAの臨床エビデンス，そして次世代の非ステロイド型MRAの可能性までをエキスパートによる解説でまとめた．</section><section class="preface">序　文<br><br>　ミネラルコルチコイド受容体拮抗薬（MRA）は従来アルドステロン拮抗薬といわれていたものである．スピロノラクトン，エプレレノンは古くからある薬であるが，降圧効果もあまり強くなく，利尿効果も弱い．さらに，高カリウム血症への懸念や糖尿病性腎症で使いにくいなど，ネガティブイメージが先行しているため実際には使用頻度はあまり高くない．これらの薬がアルドステロン拮抗薬ではなくなぜMRAと名称が変更されたのか，その理由すら知らない医師も多いのが現状である．そのため，レニン-アンジオテンシン-アルドステロン系という概念にとらわれるあまり，ACE阻害薬（ARB）でアルドステロンは制御可能であると考えている人も少なくない．ところが，近年，ミネラルコルチコイド受容体（MR）の新しいバイオロジーが続々と明らかになり，高血圧，慢性腎臓病（CKD），メタボリックシンドローム，2型糖尿病，動脈硬化そして心不全の病態進展に重要な役割を果たすことがわかってきた．特に，収縮不全患者ではMRAは必須の薬剤である．さらに，従来のMRAの副作用を軽減させた非ステロイド型MRA が市販され，MRAの降圧を超えた多面的な心血管保護作用を再認識する必要に迫られている．本書はMRの最新の病態生理からMRAの臨床エビデンス，そして非ステロイド型MRAへの展望などをQ＆A形式でわかりやすく各分野のエキスパートに解説していただいている．<br>　日々の循環器診療にどのようにMRA を役立てたらよいかヒントを得ることができたと言っていただければ執筆者一同の喜びである．<br><br>2019年2月<br>伊藤　浩</section><section class="indexes">PART 1 アルドステロンとMRを理解する<br>Q1　ミネラルコルチコイド受容体（MR）はどのようなものでしょうか？ その働きとともに教えてください<br>Q2　MRの腎上皮細胞における作用を教えてください<br>Q3　MRは腎臓以外に広く分布すると聞きました．どのような臓器に分布するのか，そしてその役割についても教えてください<br>Q4　アルドステロンは副腎皮質だけでなく他の組織でも産生されると聞きました．それに関して教えてください<br>Q5　組織にはコルチゾールが高濃度存在し，アルドステロンとほぼ同じ親和性でMRに結合すると聞きました．なぜ，腎上皮細胞ではMRにアルドステロンのみ作用するのでしょうか？<br>Q6　組織にはコルチゾールが高濃度存在し，アルドステロンとほぼ同じ親和性でMR に結合すると聞きました．心筋のMRではコルチゾールとアルドステロンがどのような関係になるのでしょうか？<br>Q7　なぜアルドステロン拮抗薬ではなく，ミネラルコルチコイド受容体拮抗薬（MRA）と呼ぶようになったのでしょうか？<br>Q8　アルドステロンの非上皮作用（腎上皮以外）に関して教えてください<br>Q9　アルドステロンとアンジオテンシンIIおよび交感神経系との相互作用に関して教えてください<br>Q10　アルドステロンのゲノム作用と非ゲノム作用を教えてください<br>Q11　MRはどのようなとき，あるいは刺激で活性化されるのでしょうか？<br>Q12　心不全，CKDや2型糖尿病でMRは活性化されているのでしょうか？<br>Q13　MRAに抗炎症作用効果があると聞きました．その機序に関して教えてください<br>Q14　MR活性化の中枢神経に対する生理的そして病的作用について教えてください<br>Q15　MR活性化の血管に対する病的作用に関して教えてください<br>Q16　MR活性化の心臓に対する病的作用に関して教えてください<br>Q17　MR活性化の腎臓に対する病的作用に関して教えてください<br>Q18　ACE阻害薬そしてARBでも出現するアルドステロンブレークスルーの機序と病的意義を教えてください<br>PART 2 MRAの臨床効果を検証する<br>降圧薬としてのMRA<br>Q19　欧米，日本の高血圧ガイドラインにおけるMRAの位置づけを教えてください<br>Q20　スピロノラクトンとエプレレノンの使い分けに関して教えてください<br>Q21　ACE阻害薬・ARBにMRAを加えるときのメリットと注意点を教えてください<br>Q22　MRAと併用するとより強い降圧効果が得られる組み合わせを教えてください<br>Q23　原発性アルドステロン症の病態と治療方針を教えてください<br>心不全<br>Q24　MRAの多施設共同試験を解説する（HFrEF）：RALES試験<br>Q25　MRAの多施設共同試験を解説する（HFrEF）：EMPHASIS-HF研究とJ-EMPHASISHF研究<br>Q26　HFrEF患者にはtriple blockadeが必要といわれています．なぜ，ACE阻害薬やβ遮断薬にMRAを加えると相加効果を出すのでしょうか？<br>Q27　HFrEF患者ではACE阻害薬やARBを最大限まで使用しないとMRAを併用してはいけないのでしょうか？ あるいは，MRAの先行投与はいけないのでしょうか？<br>Q28　HFrEF患者の入院急性期からMRAを使用したほうがよいでしょうか？<br>Q29　HFrEF患者にMRAを用いる場合に徐々に増量したほうがよいでしょうか？<br>Q30　ガイドラインではNYHA II度からMRAが推奨されていますが，NYHA I度の患者には使用すべきでしょうか？<br>Q31　超重症のHFrEF患者にもMRAは使うべきでしょうか？<br>Q32　MRAはHFrEF患者の突然死を減少させると聞きました．そのエビデンスと機序を教えてください<br>Q33　MRAの多施設共同試験を解説する（HFpEF）：TOPCAT試験<br>Q34　HFpEF患者にはMRA は無効なのでしょうか？ 軽症例に使用するメリットはあるでしょうか？<br>Q35　MRAの多施設共同試験を解説する（心筋梗塞）：EPHESUS試験<br>Q36　MRAには交感神経抑制作用があるのでしょうか？<br>Q37　どのような心筋梗塞患者にMRAが推奨されるのでしょうか？<br>Q38　MRAの心肥大抑制効果に関して教えてください<br>Q39　MRAでしばしば高K血症が問題になりますが，心不全患者における適正な血清K値に関して教えてください<br>血管保護作用<br>Q40　MRAの血管内皮機能とスティフネスに対する効果を教えてください<br>Q41　MRAの心血管イベント予防効果とその機序に関して教えてください<br>利尿薬としてのMRA<br>Q42　ループ利尿薬単独よりもMRAを加えたほうがよいといわれています．なぜなのでしょうか？ その理由を教えてください<br>Q43　慢性心不全患者の利尿におけるMRAそしてサイアザイドの役割を教えてください<br>腎保護効果<br>Q44　MRAは腎不全患者で使いにくい印象があります．腎保護効果はあるのでしょうか？<br>Q45　MRAは糖尿病性腎症の蛋白尿に対する効果があると聞きました．そのエビデンスと機序を教えてください<br>状況別使用法<br>Q46　75歳以上の高齢高血圧患者に対するMRAの適応と注意点に関して教えてください<br>Q47　高血圧を合併する2型糖尿病患者にMRAを使用するメリットと注意点を教えてください<br>MRA の副作用とその対策<br>Q48　MRAで誘発される高K血症の機序とそのハイリスク群を教えてください<br>Q49　MRAの高K血症対策：どこまで許容し，どのように対応したらよいのか教えてください<br>Q50　MRAの禁忌に関して教えてください<br>PART 3次世代MRAの可能性を探る<br>Q51　非ステロイド型MRAとはどのようなものでしょうか？<br>Q52　非ステロイド型MRAはスピロノラクトン，エプレレノンと異なり，どのような利点があるのでしょうか？<br>Q53　非ステロイド型MRAにはどのようなものがあるのでしょうか？<br>Q54　非ステロイド型MRAの降圧効果に関して教えてください<br>Q55　非ステロイド型MRAの腎保護効果の機序と糖尿病性腎症に対する効果に関して教えてください<br>Q56　非ステロイド型MRAの心不全に対する効果に関して教えてください<br>Q57　非ステロイド型MRAの副作用に関して教えてください<br>索引</section></article>
	</section>


</main>

<footer>
	<ul class="footer_list">
		<li>
			<a href="/company.html">会社案内</a>
		</li>
		<li>
			<a href="/recruit.html">採用情報</a>
		</li>
		<li>
			<a href="/privacy.html">プライバシーポリシー</a>
		</li>
		<li>
			<a href="/terms.html">利用規約</a>
		</li>
		<li>
			<a href="/act.html">特定商取引法に基づく表示</a>
		</li>
		<li>
			<a href="/order.html">ご注文について</a>
		</li>
		<li>
			<a href="/adinfo.html">広告掲載案内</a>
		</li>
		<li>
			<a href="/inquiry.html">お問い合わせ</a>
		</li>
	</ul>
	<p class="copyright">Copyright&nbsp;&copy;&nbsp;Bunkodo&nbsp;Co.,&nbsp;Ltd.&nbsp;All rights reserved</p>
</footer>


</body>
</html>